Gene
dbi
- ID
- ZDB-GENE-040426-1861
- Name
- diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
- Symbol
- dbi Nomenclature History
- Previous Names
-
- wu:fb63e10
- zgc:56108
- zgc:77734
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in gut. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56108 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA-binding protein, ACBP | Acyl-CoA-binding protein, ACBP, conserved site | Acyl-CoA binding protein superfamily | FERM/acyl-CoA-binding protein superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:E9QFI5 | InterPro | 85 | ||||
| UniProtKB:Q6P5L2 | InterPro | 87 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250A16 | ZFIN Curated Data | |
| Encodes | EST | fb63e10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56108 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77734 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191607 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199608 (1) | 1496 nt | ||
| Genomic | GenBank:CU463316 (1) | 96317 nt | ||
| Polypeptide | UniProtKB:Q6P5L2 (1) | 87 aa |
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Shi, G., Cui, Q., Wang, J., Guo, H., Pan, Y., Sheng, N., Guo, Y., Dai, J. (2019) Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring. Environmental pollution (Barking, Essex : 1987). 249:550-559
- Teixeira, C.M.M., Correa, C.N., Iwai, L.K., Ferro, E.S., Castro, L.M. (2019) Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Zebrafish. 16(3):240-251
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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