Gene
scp2a
- ID
- ZDB-GENE-040426-1846
- Name
- sterol carrier protein 2a
- Symbol
- scp2a Nomenclature History
- Previous Names
-
- scp2
- zgc:77634
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable C-acyltransferase activity; lipid binding activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to act upstream of or within lipid transport. Predicted to be located in mitochondrion. Predicted to be active in peroxisome. Is expressed in intestinal bulb; lens; liver; and solid lens vesicle. Orthologous to human SCP2 (sterol carrier protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77634 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Leukoencephalopathy with dystonia and motor neuropathy | 613724 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SCP2 sterol-binding domain | SCP2 sterol-binding domain superfamily | Thiolase, acyl-enzyme intermediate active site | Thiolase, conserved site | Thiolase, C-terminal domain 2 | Thiolase-like | Thiolase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P4V5 | InterPro PDB | 538 | |||||||
| UniProtKB:A0A8M2BA96 | InterPro | 332 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284B7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77634 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200865 (1) | 2334 nt | ||
| Genomic | GenBank:AL954171 (1) | 148854 nt | ||
| Polypeptide | UniProtKB:Q6P4V5 (1) | 538 aa |
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Jia, Z., Zhao, C., Wang, M., Zhao, X., Zhang, W., Han, T., Xia, Q., Han, Z., Lin, R., Li, X. (2019) Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 121:109558
- Kim, Y.I., Nam, I.K., Lee, D.K., Bhandari, S., Charton, L., Kwak, S., Lim, J.Y., Hong, K., Kim, S.J., Lee, J.N., Kwon, S.W., So, H.S., Linka, N., Park, R., Choe, S.K. (2019) Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish. Journal of Cellular Physiology. 235(1):151-165
- Pfeiffer, J., Tarbashevich, K., Bandemer, J., Palm, T., Raz, E. (2018) Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90. Developmental Biology. 436(2):84-93
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
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