Gene
acsl4a
- ID
- ZDB-GENE-040426-1565
- Name
- acyl-CoA synthetase long chain family member 4a
- Symbol
- acsl4a Nomenclature History
- Previous Names
-
- acsl4
- acsl4b
- zgc:66186 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable arachidonate-CoA ligase activity. Acts upstream of or within dorsal/ventral pattern formation and regulation of signal transduction. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66186 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Miyares et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35699 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 63 | Alliance | Intellectual developmental disorder, X-linked 63 | 300387 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AMP-binding | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6PFP1
|
706 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl4a-201
(1)
|
Ensembl | 3,852 nt | ||
| mRNA |
acsl4a-202
(1)
|
Ensembl | 2,154 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.8fabp10a:acsl4a,cryaa:mCherry) |
|
| 1 | Freeburg et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-86C12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-18F5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66186 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191744 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200649 (1) | 3863 nt | ||
| Genomic | GenBank:BX088535 (1) | 197465 nt | ||
| Polypeptide | UniProtKB:Q6PFP1 (1) | 706 aa |
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Gao, S.Y., Zhao, J.C., Xia, Q., Sun, C., Aili, M., Talifu, A., Huo, S.X., Zhang, Y., Li, Z.J. (2024) Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in pharmacology. 15:13086551308655
- Jiang, Z., Deng, L., Xiang, G., Xu, X., Wang, Y. (2024) A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression. Antioxidants (Basel, Switzerland). 13(4):
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Blanc, M., Alfonso, S., Bégout, M.L., Barrachina, C., Hyötyläinen, T., Keiter, S.H., Cousin, X. (2020) An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. The Science of the total environment. 754:142097
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
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