Gene
ilk
- ID
- ZDB-GENE-040426-1435
- Name
- integrin-linked kinase
- Symbol
- ilk Nomenclature History
- Previous Names
-
- loc
- lost-contact
- main squeeze
- msq
- zgc:65842
- zilk (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables protein kinase activity. Acts upstream of or within several processes, including circulatory system development; muscle attachment; and tendon development. Located in Z disc and sarcolemma. Is expressed in brain; cardiovascular system; muscle; myoblast; and somite. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65842 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ilk | N/A | (7) |
| MO2-ilk | N/A | (5) |
| MO3-ilk | N/A | Friedrich et al., 2004 |
| MO4-ilk | N/A | Postel et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR035692 | Integrin-linked protein kinase, pseudokinase domain |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Integrin-linked protein kinase, pseudokinase domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PHD6 | InterPro | 452 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-287A12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65842 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200571 (1) | 3170 nt | ||
| Genomic | GenBank:AL928852 (2) | 157466 nt | ||
| Polypeptide | UniProtKB:Q6PHD6 (1) | 452 aa |
- Chen, J., Ding, J., Li, Y., Feng, F., Xu, Y., Wang, T., He, J., Cang, J., Luo, L. (2024) Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3. Nature communications. 15:59865986
- Liang, S., Zhou, Y., Chang, Y., Li, J., Zhang, M., Gao, P., Li, Q., Yu, H., Kawakami, K., Ma, J., Zhang, R. (2024) A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration. Cellular and molecular life sciences : CMLS. 81:158158
- Zhao, Y., Liang, J., Liu, X., Li, H., Chang, C., Gao, P., Du, F., Zhang, R. (2024) Tcap deficiency impedes striated muscle function and heart regeneration with elevated ROS and autophagy. Biochimica et biophysica acta. Molecular basis of disease. 1870(8):167485
- Müller, M., Eghbalian, R., Boeckel, J.N., Frese, K.S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M.K., Tugrul, O.F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J.M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A., Cardoso-Moreira, M., Kaessmann, H., Katus, H.A., Frey, N., Steinmetz, L.M., Meder, B. (2022) NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nature communications. 13:6209
- Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778
- Li, Y., Lv, Y., Bian, C., You, X., Shi, Q. (2020) Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Gene. 769:145256
- Brodehl, A., Rezazadeh, S., Williams, T., Munsie, N.M., Liedtke, D., Oh, T., Ferrier, R., Shen, Y., Jones, S.J.M., Stiegler, A.L., Boggon, T.J., Duff, H.J., Friedman, J.M., Gibson, W.T., FORGE Canada Consortium, Childs, S.J., Gerull, B. (2019) Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. Translational research : the journal of laboratory and clinical medicine. 208:15-29
- Chang, Y., Geng, F., Hu, Y., Ding, Y., Zhang, R. (2019) Zebrafish cysteine and glycine-rich protein 3 is essential for mechanical stability in skeletal muscles. Biochemical and Biophysical Research Communications. 511(3):604-611
- Hall, T.E., Wood, A.J., Ehrlich, O., Li, M., Sonntag, C.S., Cole, N.J., Huttner, I.G., Sztal, T.E., Currie, P.D. (2019) Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A. NPJ Regenerative medicine. 4:21
- Lausser, L., Siegle, L., Rottbauer, W., Frank, D., Just, S., Kestler, H.A. (2018) Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species. Biomolecules. 8(4):
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