Gene
cyp7a1
- ID
- ZDB-GENE-040426-1296
- Name
- cytochrome P450, family 7, subfamily A, polypeptide 1
- Symbol
- cyp7a1 Nomenclature History
- Previous Names
-
- cyp7a1
- cyp7a1a
- zgc:63920 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in basal plate midbrain region; central nervous system; liver; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2450 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| rdu83 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| rdu84 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa19734 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32900 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38326 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf2169 | Allele with one deletion | Exon 4 | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyp7a1 | Enya et al., 2018 | |
| CRISPR2-cyp7a1 | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017972 | Cytochrome P450, conserved site |
| Family | IPR001128 | Cytochrome P450 |
| Family | IPR002403 | Cytochrome P450, E-class, group IV |
| Family | IPR024204 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type |
| Family | IPR030681 | Cholesterol 7-alpha-monooxygenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cholesterol 7-alpha-monooxygenase | Cytochrome P450 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450, sterol 14-alpha demethylase | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QU76 | InterPro | 512 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp7a1-201
(1)
|
Ensembl | 1,987 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:mCherry-2A-cyp7a1) |
| 1 | Enya et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198J13 | ZFIN Curated Data | |
| Encodes | EST | eu2450 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:63920 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201173 (1) | 1981 nt | ||
| Genomic | GenBank:CR450692 (1) | 180976 nt | ||
| Polypeptide | UniProtKB:F1QU76 (1) | 512 aa |
- Gao, S.Y., Zhao, J.C., Xia, Q., Sun, C., Aili, M., Talifu, A., Huo, S.X., Zhang, Y., Li, Z.J. (2024) Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in pharmacology. 15:13086551308655
- Jin, Y., Kozan, D., Young, E.D., Hensley, M., Shen, M.C., Wen, J., Moll, T., Anderson, J.L., Kozan, H., Rawls, J.F., Farber, S.A. (2024) A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis. Journal of Lipid Research. 65(10):100637
- Liu, N., Zhang, P., Xue, M., Zhang, M., Huang, Z., Xu, C., Meng, Y., Fan, Y., Liu, W., Zhang, F., Chen, P., Zhou, Y. (2024) Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet. International Journal of Molecular Sciences. 25(5):
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Wang, Y., Pan, Y., Hou, M., Luo, R., He, J., Lin, F., Xia, X., Li, P., He, C., He, P., Cheng, S., Song, Z. (2023) Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115736115736
- Wu, C., Zhang, W., Luo, Y., Cheng, C., Wang, X., Jiang, Y., Li, S., Luo, L., Yang, Y. (2023) Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis. Journal of genetics and genomics = Yi chuan xue bao. 50(12):1004-1013
- Helal, M., Yan, C., Gong, Z. (2021) Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Scientific Reports. 11:1372
- Kong, Y., Li, Y., Dai, Z.R., Qin, M., Fan, H.L., Hao, J.G., Zhang, C.X., Zhong, Q.P., Qi, C., Wang, P. (2021) Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high-cholesterol diet-fed zebrafish. Food science & nutrition. 9:5198-5210
- Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):
- Meng, H., Shang, Y., Cheng, Y., Wang, K., Yu, J., Cao, P., Fan, S., Li, Y., Cui, J. (2021) Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Biochemical and Biophysical Research Communications. 551:93-99
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