Gene
pck1
- ID
- ZDB-GENE-030909-11
- Name
- phosphoenolpyruvate carboxykinase 1 (soluble)
- Symbol
- pck1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Acts upstream of or within monoatomic ion homeostasis and response to glucose. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and visceral fat. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 48 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb856 (8 images)
- cb924 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Furukawa et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Phosphoenolpyruvate carboxykinase deficiency, cytosolic | 261680 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018091 | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site |
| Domain | IPR035077 | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain |
| Domain | IPR035078 | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal |
| Family | IPR008209 | Phosphoenolpyruvate carboxykinase, GTP-utilising |
| Homologous_superfamily | IPR008210 | Phosphoenolpyruvate carboxykinase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphoenolpyruvate carboxykinase, C-terminal | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain | Phosphoenolpyruvate carboxykinase, GTP-utilising | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal | Phosphoenolpyruvate carboxykinase, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZI9 | InterPro | 630 | ||||||
| UniProtKB:Q7T3G9 | InterPro | 630 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pck1 | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(pck1:Luciferase,cryaa:mCherry) |
|
| 1 | (8) | |
| Tg(pck1:TagGFP-DEVD-TagRFP) |
|
| 1 | Higuchi et al., 2021 | |
| Tg(pck1:Venus,cryaa:mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-127N10 | ZFIN Curated Data | |
| Encodes | EST | cb856 | Thisse et al., 2001 | |
| Encodes | EST | cb924 | Thisse et al., 2001 | |
| Encodes | EST | fc51c05 | ZFIN Curated Data | |
| Encodes | EST | fj93h11 | ||
| Encodes | cDNA | MGC:63869 | ZFIN Curated Data | |
| Has Artifact | EST | fb65b06 | ||
| Has Artifact | EST | fb65b11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214751 (1) | 2698 nt | ||
| Genomic | GenBank:CU855794 (1) | 41245 nt | ||
| Polypeptide | UniProtKB:A0A8M9PZI9 (1) | 630 aa |
- Chen, J., Ji, X., Gao, J., Huang, J., Ren, J. (2024) gys1 regulates maternal glycogen reserve essential for embryonic development in zebrafish. Heliyon. 10:e31149e31149
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Karampelias, C., Băloiu, B., Rathkolb, B., da Silva-Buttkus, P., Bachar-Wikström, E., Marschall, S., Fuchs, H., Gailus-Durner, V., Chu, L., Hrabě de Angelis, M., Andersson, O. (2024) Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration. Life science alliance. 7(11):
- Ribeiro, T., Reis, M., Vasconcelos, V., Urbatzka, R. (2024) Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics. Scientific Reports. 14:3214232142
- Shezi, M., Snyman, C., Niesler, C.U. (2024) Candidate Gene Expression in Adult Zebrafish Models of Type 2 Diabetes Mellitus. Zebrafish. 21(6):401-408
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Wu, J., Zhuang, W., Lu, K., Zhang, L., Wang, Y., Chai, F., Liang, X.F. (2024) Study on the Function of Leptin Nutrient Acquisition and Energy Metabolism of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 25(21):
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Kim, I., Seok, S.H., Lee, H.Y. (2023) Development of a Zebrafish Larvae Model for Diabetic Heart Failure With Reduced Ejection Fraction. Korean circulation journal. 53:344634-46
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
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