Gene
glud1b
- ID
- ZDB-GENE-030828-1
- Name
- glutamate dehydrogenase 1b
- Symbol
- glud1b Nomenclature History
- Previous Names
-
- cb719 (1)
- wu:fb16e02
- wu:fb58f12
- wu:fe37f03
- wu:fj43f02
- zgc:192851
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; fin; mesoderm; muscle; and tail bud. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb719 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hyperinsulinemic hypoglycemia 6 | Alliance | Hyperinsulinism-hyperammonemia syndrome | 606762 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033524 | Leu/Phe/Val dehydrogenases active site |
| Domain | IPR006096 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal |
| Domain | IPR006097 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain |
| Domain | IPR033922 | NAD(P) binding domain of glutamate dehydrogenase |
| Family | IPR006095 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | Leu/Phe/Val dehydrogenases active site | NAD(P) binding domain of glutamate dehydrogenase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P3L9 | InterPro | 542 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
glud1b-201
(1)
|
Ensembl | 2,659 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-193P11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261G23 | ZFIN Curated Data | |
| Contains | STS | chunp30314 | ||
| Encodes | EST | cb719 | Thisse et al., 2001 | |
| Encodes | EST | fb16e02 | ZFIN Curated Data | |
| Encodes | EST | fb58f12 | ZFIN Curated Data | |
| Encodes | EST | fe37f03 | ZFIN Curated Data | |
| Encodes | EST | fj43f02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55630 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77590 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199545 (1) | 2659 nt | ||
| Genomic | GenBank:CR931998 (1) | 144369 nt | ||
| Polypeptide | UniProtKB:Q6P3L9 (1) | 542 aa |
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Wu, X., Chen, J., Liu, C., Wang, X., Zhou, H., Mai, K., He, G. (2022) Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387
- Han, S.L., Liu, Y., Limbu, S.M., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish. Fish physiology and biochemistry. 47(1):173-188
- Li, L.Y., Lv, H.B., Jiang, Z.Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. The Journal of physiology. 598(20):4537-4553
- Wang, K., Liu, C., Hou, Y., Zhou, H., Wang, X., Mai, K., He, G. (2019) Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Frontiers in endocrinology. 10:356
- Li, J.M., Li, L.Y., Qin, X., Degrace, P., Demizieux, L., Limbu, S.M., Wang, X., Zhang, M.L., Li, D.L., Du, Z.Y. (2018) Inhibited Carnitine Synthesis Causes Systemic Alteration of Nutrient Metabolism in Zebrafish. Frontiers in Physiology. 9:509
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Li, J.M., Li, L.Y., Qin, X., Ning, L.J., Lu, D.L., Li, D.L., Zhang, M.L., Wang, X., Du, Z.Y. (2017) Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports. 7:40815
- Tian, J., Wang, K., Wang, X., Wen, H., Zhou, H., Liu, C., Mai, K., He, G. (2017) Soybean Saponin Modulates Nutrient Sensing Pathways and Metabolism in Zebrafish. General and comparative endocrinology. 257:246-254
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