Gene
mapk1
- ID
- ZDB-GENE-030722-2
- Name
- mitogen-activated protein kinase 1
- Symbol
- mapk1 Nomenclature History
- Previous Names
-
- ERK2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within gastrulation. Predicted to be located in centrosome and spindle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56570 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 13 | Alliance | Noonan syndrome 13 | 619087 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR008349 | Mitogen-activated protein (MAP) kinase, ERK1/2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Mitogen-activated protein (MAP) kinase, ERK1/2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZW72 | InterPro | 369 |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-mapk | monoclonal | IgG1 | Mouse |
|
Sigma-Aldrich
|
25 | |
| Ab3-mapk | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
9 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-72G15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56570 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77792 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182888 (1) | 1651 nt | ||
| Genomic | GenBank:BX005237 (1) | 213290 nt | ||
| Polypeptide | UniProtKB:Q7ZW72 (1) | 369 aa |
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Fang, H., Wu, X.M., Hu, Y.W., Song, Y.J., Zhang, J., Chang, M.X. (2020) NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and comparative immunology. 112:103769
- Gong, L., Yu, L., Gong, X., Wang, C., Hu, N., Dai, X., Peng, C., Li, Y. (2020) Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses. Journal of neuroinflammation. 17:173
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Naderi, M., Salahinejad, A., Attaran, A., Chivers, D.P., Niyogi, S. (2020) Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Environmental pollution (Barking, Essex : 1987). 261:114060
- Zhang, J., Deng, Y., Cheng, B., Huang, Y., Meng, Y., Zhong, K., Xiong, G., Guo, J., Liu, Y., Lu, H. (2020) Protective effects and molecular mechanisms of baicalein on thioacetamide-induced toxicity in zebrafish larvae. Chemosphere. 256:127038
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