Gene
fgf10a
- ID
- ZDB-GENE-030715-1
- Name
- fibroblast growth factor 10a
- Symbol
- fgf10a Nomenclature History
- Previous Names
-
- fgf10
- dae
- daedalus
- wu:fd11d03 (1)
- zgc:109774
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable chemoattractant activity; growth factor activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 103 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109774 (13 images)
- eu110 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fgf10a | N/A | (4) |
| MO2-fgf10a | N/A | Nomura et al., 2006 |
| MO3-fgf10a | N/A | (5) |
| MO4-fgf10a | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aplasia of lacrimal and salivary glands | Alliance | Aplasia of lacrimal and salivary glands | 180920 |
| lacrimoauriculodentodigital syndrome 3 | Alliance | LADD syndrome 3 | 620193 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:Q8AY90 | InterPro | 201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fgf10a-201
(1)
|
Ensembl | 2,005 nt | ||
| mRNA |
fgf10a-202
(1)
|
Ensembl | 2,383 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(fgf10a:EGFP-fgf10a,cryaa:DsRed) |
|
| 1 | Wang et al., 2018 | |
| TgBAC(fgf10a:SEC-EGFP,cryaa:DsRed) |
|
| 1 | Wang et al., 2018 | |
| Tg(hsp70l:fgf10a) |
|
| 1 | Wang et al., 2018 | |
| Tg(hsp70l:fgf10a-EGFP) |
|
| 1 | Jackman et al., 2013 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262I10 | ZFIN Curated Data | |
| Encodes | EST | eu110 | Thisse et al., 2005 | |
| Encodes | EST | fd11d03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109774 | ||
| Encodes | cDNA | MGC:192178 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182870 (1) | 2013 nt | ||
| Genomic | GenBank:BX927394 (2) | 164899 nt | ||
| Polypeptide | UniProtKB:Q8AY90 (1) | 201 aa |
- Jiang, X., Zhao, K., Sun, Y., Song, X., Yi, C., Xiong, T., Wang, S., Yu, Y., Chen, X., Liu, R., Yan, X., Antos, C.L. (2024) The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. PLoS Biology. 22:e3002565e3002565
- Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18
- Chen, H.J., Barske, L., Talbot, J.C., Dinwoodie, O.M., Roberts, R.R., Farmer, D.T., Jimenez, C., Merrill, A.E., Tucker, A.S., Crump, J.G. (2023) Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw. Developmental Cell. 58(6):461-473.e7
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Truong, B.T., Shull, L.C., Lencer, E., Bend, E.G., Field, M., Blue, E.E., Bamshad, M.J., Skinner, C., Everman, D., Schwartz, C.E., Flanagan-Steet, H., Artinger, K.B. (2023) PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation. Disease models & mechanisms. 16(4):
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Zagury, J.F., Sieger, D. (2022) Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Glia. 70(6):1027-1051
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Tang, D., Zheng, S., Zheng, Z., Liu, C., Zhang, J., Yan, R., Wu, C., Zuo, N., Wu, L., Xu, H., Liu, S., He, Y. (2022) Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling. Cell Proliferation. 55(5):e13225
- Yang, Y., Li, Y., Fu, J., Li, Y., Li, S., Ni, R., Yang, Q., Luo, L. (2022) Intestinal precursors avoid being misinduced to liver cells by activating Cdx-Wnt inhibition cascade. Proceedings of the National Academy of Sciences of the United States of America. 119:e2205110119
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