Gene
fgf24
- ID
- ZDB-GENE-030708-1
- Name
- fibroblast growth factor 24
- Symbol
- fgf24 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including embryonic retina morphogenesis in camera-type eye; exocrine pancreas development; and limb development. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including digestive system; fin bud; mesenchyme; mesoderm; and sensory system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu782 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgf24 | Leerberg et al., 2017 | |
| CRISPR2-fgf24 | Parvez et al., 2021 | |
| CRISPR3-fgf24 | Parvez et al., 2021 | |
| CRISPR4-fgf24 | Parvez et al., 2021 | |
| CRISPR5-fgf24 | Parvez et al., 2021 | |
| MO1-fgf24 | N/A | (8) |
| MO2-fgf24 | N/A | (9) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|
|
UniProtKB:A0A8M3AZL7
|
205 | ||
|
UniProtKB:Q0IIQ7
|
208 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1BAC(fgf24:GFP) |
|
| 1 | (2) | |
| Tg2BAC(fgf24:GFP) |
|
| 1 | (3) | |
| TgBAC(fgf24:EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-163F17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-207O21 | ZFIN Curated Data | |
| Contains | STS | unp1106 | ||
| Encodes | EST | eu782 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:152742 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192505 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182871 (1) | 1378 nt | ||
| Genomic | GenBank:AL831789 (2) | 217649 nt | ||
| Polypeptide | UniProtKB:Q0IIQ7 (1) | 208 aa |
No data available
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Jones, A.A., Willoner, T., Mishoe Hernandez, L., DeLaurier, A. (2023) Exposure to valproic acid (VPA) reproduces hdac1 loss of function phenotypes in zebrafish. microPublication. Biology. 2023:
- Truong, B.T., Shull, L.C., Lencer, E., Bend, E.G., Field, M., Blue, E.E., Bamshad, M.J., Skinner, C., Everman, D., Schwartz, C.E., Flanagan-Steet, H., Artinger, K.B. (2023) PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation. Disease models & mechanisms. 16(4):
- Boezio, G.L.M., Zhao, S., Gollin, J., Priya, R., Mansingh, S., Guenther, S., Fukuda, N., Gunawan, F., Stainier, D.Y.R. (2022) The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth. Disease models & mechanisms. 16(5):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Boyle-Anderson, E.A.T, Mao, Q., Ho, R.K. (2021) Tbx5a and Tbx5b paralogues act in combination to control separate vectors of migration in the fin field of zebrafish. Developmental Biology. 481:201-214
- Nakajima, W., Nakanishi, S., Hosoya, R., Uemoto, T., Ohgo, S., Wada, N. (2021) Regenerative Polarity of the Fin Ray in Zebrafish Caudal Fin and Related Tissue Formation on the Cut Surface. Journal of developmental biology. 9(4):
- Parvez, S., Herdman, C., Beerens, M., Chakraborti, K., Harmer, Z.P., Yeh, J.J., MacRae, C.A., Yost, H.J., Peterson, R.T. (2021) MIC-Drop: A platform for large-scale in vivo CRISPR screens. Science (New York, N.Y.). 373(6559):1146-1151
- Barske, L., Fabian, P., Hirschberger, C., Jandzik, D., Square, T., Xu, P., Nelson, N., Yu, H.V., Medeiros, D.M., Gillis, J.A., Crump, J.G. (2020) Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24876-24884
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