Gene

fasn

ID
ZDB-GENE-030131-7802
Name
fatty acid synthase
Symbol
fasn Nomenclature History
Previous Names
  • FAS (1)
  • fj34h12
  • wu:fj34h12
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable several functions, including (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; and acyltransferase activity, transferring groups other than amino-acyl groups. Acts upstream of or within response to (R)-carnitine. Is expressed in digestive system; male organism; muscle; subcutaneous fat; and visceral fat. Orthologous to human FASN (fatty acid synthase).
Genome Resources
Note
Transcripts from ENSDARG00000087657 in Ensembl GRCz11 are associated with ccdc57 and fasn. fasn-202 (ENSDART00000124982) should be associated with ccdc57. Other transcripts belong with fasn. Alternate gene (haplotype) in GRCz11 is ENSDARG00000113553.
Comparative Information
Expression
All Expression Data
69 figures from 61 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fasn Human Ortholog
No data available
Associated With fasn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018201 Beta-ketoacyl synthase, active site
Domain IPR001031 Thioesterase
Domain IPR009081 Phosphopantetheine binding ACP domain
Domain IPR014030 Beta-ketoacyl synthase-like, N-terminal
Domain IPR014031 Beta-ketoacyl synthase, C-terminal
1 - 5 of 23 Show all
Domain Details Per Protein
Protein Additional Resources Length ACP-like superfamily Acyl transferase/acyl hydrolase/lysophospholipase Acyl transferase domain Acyl transferase domain superfamily Alpha/Beta hydrolase fold Beta-ketoacyl synthase, active site Beta-ketoacyl synthase, C-terminal Beta-ketoacyl synthase-like, N-terminal Fatty acid synthase, pseudo-KR domain GroES-like superfamily Malonyl-CoA ACP transacylase, ACP-binding NAD(P)-binding domain superfamily Phosphopantetheine attachment site Phosphopantetheine binding ACP domain Polyketide and Nonribosomal Peptide Biosynthesis Enzymes Polyketide synthase, beta-ketoacyl synthase domain Polyketide synthase, C-terminal extension Polyketide synthase, dehydratase domain, N-terminal Polyketide synthase, dehydratase domain superfamily Polyketide synthase-like, phosphopantetheine-binding domain S-adenosyl-L-methionine-dependent methyltransferase superfamily Thioesterase Thiolase-like
UniProtKB:E7F5V3 InterPro 2514
UniProtKB:F8W3U6 InterPro
UniProtKB:A0A8M9Q0T1 InterPro 724
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Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fasn-201 (1)
Ensembl
Ensembl 7,536 nt
ZFIN BLAST
mRNA fasn-203 (1)
Ensembl
Ensembl 10,042 nt
ZFIN BLAST
mRNA fasn-204 (1)
Ensembl
Ensembl 485 nt
ZFIN BLAST
mRNA fasn-205 (1)
Ensembl
Ensembl 281 nt
ZFIN BLAST
mRNA fasn-206 (1)
Ensembl
Ensembl 171 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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