Gene
acsbg2
- ID
- ZDB-GENE-030131-7099
- Name
- acyl-CoA synthetase bubblegum family member 2
- Symbol
- acsbg2 Nomenclature History
- Previous Names
-
- fj55d04
- fk81d02
- im:7046047
- sb:cb76
- si:dkey-240a9.3
- wu:fj55d04
- wu:fk81d02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; neural tube; optic vesicle; trigeminal placode; and ventral mesoderm. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb76 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026393Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa27178 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34372 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44683 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1NJ75 | InterPro | 752 | |||
| UniProtKB:F1RCV2 | InterPro | 742 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsbg2-201
(1)
|
Ensembl | 2,845 nt | ||
| mRNA |
acsbg2-202
(1)
|
Ensembl | 4,124 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-240A9 | ZFIN Curated Data | |
| Encodes | EST | cb76 | Thisse et al., 2001 | |
| Encodes | EST | fj55d04 | ||
| Encodes | EST | fk81d02 | ||
| Encodes | EST | IMAGE:7046047 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126379 (1) | 4080 nt | ||
| Genomic | GenBank:BX664738 (1) | 180024 nt | ||
| Polypeptide | UniProtKB:A0A8M1NJ75 (1) | 752 aa |
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Wang, X., Sun, S., Cao, X., Gao, J. (2020) Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish. International Journal of Molecular Sciences. 21(8):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Watkins, P.A., Maiguel, D., Jia, Z., and Pevsner, J. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Journal of Lipid Research. 48(12):2736-2750
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