Gene
cpt2
- ID
- ZDB-GENE-030131-6719
- Name
- carnitine palmitoyltransferase 2
- Symbol
- cpt2 Nomenclature History
- Previous Names
-
- wu:fa03e08
- wu:fb54a02
- zgc:101627
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle; intestine; and liver. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101627 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016296Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026408Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cpt2 | N/A | Baker et al., 2024 |
| MO2-cpt2 | N/A | Baker et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carnitine palmitoyltransferase II deficiency | Alliance | CPT II deficiency, infantile | 600649 |
| carnitine palmitoyltransferase II deficiency | Alliance | CPT II deficiency, lethal neonatal | 608836 |
| carnitine palmitoyltransferase II deficiency | Alliance | CPT II deficiency, myopathic, stress-induced | 255110 |
| {Encephalopathy, acute, infection-induced, 4, susceptibility to} | 614212 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR039551 | Choline/carnitine acyltransferase domain |
| Family | IPR000542 | Acyltransferase ChoActase/COT/CPT |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR042231 | Choline/Carnitine o-acyltransferase, domain 2 |
| Homologous_superfamily | IPR042572 | Carnitine o-acyltransferase, N-terminal |
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Domain Details Per Protein
| Protein | Length | Acyltransferase ChoActase/COT/CPT | Carnitine o-acyltransferase, N-terminal | Chloramphenicol acetyltransferase-like domain superfamily | Choline/carnitine acyltransferase domain | Choline/Carnitine o-acyltransferase, domain 2 |
|---|---|---|---|---|---|---|
|
UniProtKB:B2GQ15
|
668 | |||||
|
UniProtKB:Q5U3U3
|
669 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-216K22 | ZFIN Curated Data | |
| Contains | SNP | rs3728147 | ZFIN Curated Data | |
| Encodes | EST | fa03e08 | ||
| Encodes | EST | fb54a02 | ||
| Encodes | cDNA | MGC:101627 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191737 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007447 (1) | 2596 nt | ||
| Genomic | GenBank:BX927144 (1) | 168503 nt | ||
| Polypeptide | UniProtKB:Q5U3U3 (1) | 669 aa |
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Gao, S.Y., Zhao, J.C., Xia, Q., Sun, C., Aili, M., Talifu, A., Huo, S.X., Zhang, Y., Li, Z.J. (2024) Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in pharmacology. 15:13086551308655
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Frontiers in nutrition. 8:797510
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Xu, H., Jiang, Y., Miao, X.M., Tao, Y.X., Xie, L., Li, Y. (2021) A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. Biology. 10(2):
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