Gene
aqp7
- ID
- ZDB-GENE-030131-6461
- Name
- aquaporin 7
- Symbol
- aqp7 Nomenclature History
- Previous Names
-
- fj98f09
- wu:fj98f09
- zgc:63700
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables glycerol transmembrane transporter activity; urea transmembrane transporter activity; and water transmembrane transporter activity. Acts upstream of or within glycerol transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including brain; mucus secreting cell; neural crest; pleuroperitoneal region; and vasculature. Orthologous to several human genes including AQP7 (aquaporin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63700 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23873 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Glycerol quantitative trait locus] | 614411 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aquaporin-like | Major intrinsic protein | Major Intrinsic Protein/Aquaporin |
|---|---|---|---|---|---|
| UniProtKB:D3TZW4 | InterPro | 303 | |||
| UniProtKB:A0A8M9P367 | InterPro | 279 | |||
| UniProtKB:A0A8M2B7X7 | InterPro | 310 | |||
| UniProtKB:A0AB32TD23 | InterPro | 303 | |||
| UniProtKB:A0AB32TES5 | InterPro | 272 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260M19 | ZFIN Curated Data | |
| Encodes | EST | fj98f09 | ||
| Encodes | cDNA | MGC:63700 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199910 (1) | 1094 nt | ||
| Genomic | GenBank:CT027620 (2) | 162438 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7X7 (1) | 310 aa |
- Zhong, X., Zhang, G., Huang, J., Chen, L., Shi, Y., Wang, D., Zheng, Q., Su, H., Li, X., Wang, C., Zhang, J., Guo, L. (2024) Effects of Intestinal Microbiota on the Biological Transformation of Arsenic in Zebrafish: Contribution and Mechanism. Environmental science & technology. 58(5):2247-2259
- Qin, Y., Wang, S., Duan, X., Liu, D. (2019) Expression analysis of the aquaporins during zebrafish embryonic development. Gene expression patterns : GEP. 32:38-43
- Dong, C., Chen, L., Feng, J., Xu, J., Mahboob, S., Al-Ghanim, K., Li, X., Xu, P. (2016) Genome Wide Identification, Phylogeny, and Expression of Aquaporin Genes in Common Carp (Cyprinus carpio). PLoS One. 11:e0166160
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Horng, J.L., Chao, P.L., Chen, P.Y., Shih, T.H., Lin, L.Y. (2015) Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport. PLoS One. 10:e0136440
- Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131
- Chauvigné, F., Lubzens, E., and Cerdà, J. (2011) Design and characterization of genetically engineered zebrafish aquaporin-3 mutants highly permeable to the cryoprotectant ethylene glycol. BMC Biotechnology. 11:34
- Tingaud-Sequeira, A., Calusinska, M., Finn, R.N., Chauvigne, F., Lozano, J., and Cerda, J. (2010) The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals. BMC Evolutionary Biology. 10:38
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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