Gene
acsl3b
- ID
- ZDB-GENE-030131-492
- Name
- acyl-CoA synthetase long chain family member 3b
- Symbol
- acsl3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7155129 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:B0S5C4
|
711 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl3b-201
(1)
|
Ensembl | 4,613 nt | ||
| mRNA |
acsl3b-202
(1)
|
Ensembl | 5,022 nt | ||
| mRNA |
acsl3b-203
(1)
|
Ensembl | 6,680 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20F20 | Minchin et al., 2008 | |
| Encodes | EST | fa07a08 | ||
| Encodes | EST | fb34c03 | ||
| Encodes | EST | IMAGE:7155129 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145932 (1) | 4613 nt | ||
| Genomic | GenBank:BX085193 (1) | 246911 nt | ||
| Polypeptide | UniProtKB:B0S5C4 (1) | 711 aa |
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Quinlivan, V.H., Farber, S.A. (2017) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Frontiers in endocrinology. 8:319
- Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y.A., Hamrick, M.W. (2016) Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochemical and Biophysical Research Communications. 479(3):590-595
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cruz-Garcia, L., Schlegel, A. (2014) Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. Journal of Lipid Research. 55(9):1944-58
- Lopes-Marques, M., Cunha, I., Reis-Henriques, M.A., Santos, M.M., and Castro, L.F. (2013) Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. BMC Developmental Biology. 13:271
- Minchin, J.E., and Hughes, S.M. (2008) Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest. Developmental Biology. 317(2):508-522
- Watkins, P.A., Maiguel, D., Jia, Z., and Pevsner, J. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Journal of Lipid Research. 48(12):2736-2750
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