Gene
cpt1ab
- ID
- ZDB-GENE-030131-3250
- Name
- carnitine palmitoyltransferase 1Ab (liver)
- Symbol
- cpt1ab Nomenclature History
- Previous Names
-
- fc31g06
- si:ch211-236l14.3
- wu:fc31g06 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable carnitine O-palmitoyltransferase activity. Acts upstream of or within regulation of fatty acid beta-oxidation. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle and liver. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zecchin et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14518 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24683 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25226 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38079 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38080 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38081 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38082 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cpt1ab | Zhou et al., 2023 | |
| MO1-cpt1ab | N/A | Zecchin et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carnitine palmitoyltransferase I deficiency | Alliance | CPT deficiency, hepatic, type IA | 255120 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR032476 | Carnitine O-palmitoyltransferase, N-terminal |
| Domain | IPR039551 | Choline/carnitine acyltransferase domain |
| Family | IPR000542 | Acyltransferase ChoActase/COT/CPT |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR042231 | Choline/Carnitine o-acyltransferase, domain 2 |
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Domain Details Per Protein
| Protein | Length | Acyltransferase ChoActase/COT/CPT | Carnitine O-palmitoyltransferase, N-terminal | Chloramphenicol acetyltransferase-like domain superfamily | Choline/carnitine acyltransferase domain | Choline/Carnitine o-acyltransferase, domain 2 |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PEG9
|
775 | |||||
|
UniProtKB:A0A8M9PNB1
|
428 | |||||
|
UniProtKB:A0A8M9PR97
|
774 | |||||
|
UniProtKB:K7DY29
|
774 | |||||
|
UniProtKB:A0A8M9PXF3
|
428 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cpt1ab-201
(1)
|
Ensembl | 5,195 nt | ||
| mRNA |
cpt1ab-202
(1)
|
Ensembl | 3,570 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-236L14 | ZFIN Curated Data | |
| Contains | STS | unp1694 | ||
| Encodes | EST | fc31g06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473872 (1) | 3310 nt | ||
| Genomic | GenBank:AL928941 (2) | 146652 nt | ||
| Polypeptide | UniProtKB:A0A8M9PEG9 (1) | 775 aa |
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Zhou, W.H., Luo, Y., Li, R.X., Degrace, P., Jourdan, T., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2023) Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of raptor in zebrafish. The Journal of biological chemistry. 299(10):105220
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Guo, W., Lei, L., Shi, X., Li, R., Wang, Q., Han, J., Yang, L., Chen, L., Zhou, B. (2021) Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environmental science & technology. 55(10):6926-6935
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Xu, H., Jiang, Y., Miao, X.M., Tao, Y.X., Xie, L., Li, Y. (2021) A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. Biology. 10(2):
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., Liu, C. (2021) Perfluorooctane Sulfonate Promotes Doxycycline-induced Liver Tumor Progression in Male Krasv12 Transgenic Zebrafish. Environmental research. 196:110962
- Bayır, M., Arslan, G., Bayır, A. (2020) Identification and Characterization of Carnitine Palmitoyltransferase 1 (cpt 1) Genes in Nile Tilapia, Oreochromis niloticus. Evolutionary bioinformatics online. 16:1176934320913255
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