Gene
mtor
- ID
- ZDB-GENE-030131-2974
- Name
- mechanistic target of rapamycin kinase
- Symbol
- mtor Nomenclature History
- Previous Names
-
- ztor (1)
- frap1
- wu:fc22h08
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including defense response to bacterium; positive regulation of myelination; and regulation of TOR signaling. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; male organism; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144752 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq69 | Allele with one deletion | Exon 5 | Unknown | not specified | |
| fh178 | unknown | Unknown | Unknown | ENU | |
| la016408Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16755 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21374 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30906 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34485 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38710 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mtor | (2) | |
| CRISPR2-mtor | Ding et al., 2022 | |
| CRISPR3-mtor | Bu et al., 2021 | |
| CRISPR4-mtor | Xiao et al., 2024 | |
| CRISPR5-mtor | Xia et al., 2024 | |
| MO1-mtor | N/A | (7) |
| MO2-mtor | N/A | Makky et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR009076 | FKBP12-rapamycin binding domain |
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Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | FKBP12-rapamycin binding domain | FKBP12-rapamycin binding domain superfamily | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Serine/threonine-protein kinase mTOR domain | Serine/threonine-protein kinase TOR, catalytic domain | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q06RG6
|
2515 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-95C6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-119D14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-220J14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-75A21 | ZFIN Curated Data | |
| Encodes | EST | fc22h08 | ||
| Encodes | EST | IMAGE:7144752 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077211 (1) | 8527 nt | ||
| Genomic | GenBank:AL844179 (1) | 182105 nt | ||
| Polypeptide | UniProtKB:Q06RG6 (1) | 2515 aa |
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Xia, J., Wang, H., Zhong, Z., Jiang, J. (2024) Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling. Cells. 13(11):
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