Gene
glud1a
- ID
- ZDB-GENE-030114-2
- Name
- glutamate dehydrogenase 1a
- Symbol
- glud1a Nomenclature History
- Previous Names
-
- glud1
- cb622 (1)
- wu:fc33g09
- wu:fc66a10
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; periderm; and pronephros. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb622 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-glud1a | LaCoursiere et al., 2024 | |
| CRISPR2-glud1a | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hyperinsulinemic hypoglycemia 6 | Alliance | Hyperinsulinism-hyperammonemia syndrome | 606762 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033524 | Leu/Phe/Val dehydrogenases active site |
| Domain | IPR006096 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal |
| Domain | IPR006097 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain |
| Domain | IPR033922 | NAD(P) binding domain of glutamate dehydrogenase |
| Family | IPR006095 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacid dehydrogenase-like, N-terminal domain superfamily | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | Leu/Phe/Val dehydrogenases active site | NAD(P) binding domain of glutamate dehydrogenase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NZ29 | InterPro | 544 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
glud1a-201
(1)
|
Ensembl | 2,482 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134M17 | ZFIN Curated Data | |
| Encodes | EST | cb622 | Thisse et al., 2001 | |
| Encodes | EST | fc33g09 | ZFIN Curated Data | |
| Encodes | EST | fc66a10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77186 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212576 (1) | 2520 nt | ||
| Genomic | GenBank:BX005174 (1) | 178371 nt | ||
| Polypeptide | UniProtKB:Q6NZ29 (1) | 544 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Ding, Q., Lu, C., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringo, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Frontiers in nutrition. 9:894278
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- Wang, J.G., Zhao, S.H., Qian, Y.C., Qian, Y.F., Liu, Y.C., Qiao, F., Luo, Y., Zhang, M.L., Du, Z.Y. (2022) The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism. The British journal of nutrition. 130(4):588-603
- Wu, X., Chen, J., Liu, C., Wang, X., Zhou, H., Mai, K., He, G. (2022) Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
- Gong, G., Chen, H., Kam, H., Chan, G., Tang, Y.X., Wu, M., Tan, H., Tse, Y.C., Xu, H.X., Lee, S.M. (2020) In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions. Journal of natural products. 83(12):3706-3716
- Li, L.Y., Li, J.M., Ning, L.J., Lu, D.L., Luo, Y., Ma, Q., Limbu, S.M., Li, D.L., Chen, L.Q., Lodhi, I.J., Degrace, P., Zhang, M.L., Du, Z.Y. (2020) Mitochondrial Fatty Acid β-Oxidation Inhibition Promotes Glucose Utilization and Protein Deposition through Energy Homeostasis Remodeling in Fish. The Journal of nutrition. 150(9):2322-2335
- Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763
- Fu, J., Tan, Y.X.R., Gong, Z., Bae, S. (2019) The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Ecotoxicology and environmental safety. 189:110039
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