Gene
fads2
- ID
- ZDB-GENE-011212-1
- Name
- fatty acid desaturase 2
- Symbol
- fads2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within liver development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alar plate midbrain region; fat cell; nervous system; optic vesicle; and pleuroperitoneal region. Orthologous to several human genes including FADS2 (fatty acid desaturase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56438 (3 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fads2 | (2) | |
| CRISPR2-fads2 | Zhao et al., 2020 | |
| CRISPR3-fads2 | Bláhová et al., 2022 | |
| MO1-fads2 | N/A | Liu et al., 2013 |
| MO2-fads2 | N/A | Liu et al., 2013 |
| TALEN1-fads2 | Ashikawa et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b5-like heme/steroid binding domain | Cytochrome b5-like heme/steroid binding domain superfamily | Fatty acid desaturase | Fatty acid desaturase domain |
|---|---|---|---|---|---|---|
| UniProtKB:A9JSU3 | InterPro | |||||
| UniProtKB:Q9DEX7 | InterPro | 444 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-273G8 | ZFIN Curated Data | |
| Contains | SSLP | z975 | ||
| Encodes | EST | fb64c04 | Hastings et al., 2001 | |
| Encodes | EST | fb69e08 | ||
| Encodes | cDNA | MGC:56438 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171535 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173924 | ZFIN Curated Data | |
| interacts with | Promoter | fads2_promoter | Tay et al., 2018 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131645 (1) | 1708 nt | ||
| Genomic | GenBank:CU694371 (2) | 83266 nt | ||
| Polypeptide | UniProtKB:Q9DEX7 (1) | 444 aa |
- Chen, Z., He, M., Wang, H., Li, X., Qin, R., Ye, D., Zhai, X., Zhu, J., Zhang, Q., Hu, P., Shui, G., Sun, Y. (2024) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids. Nature communications. 15:97699769
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Lou, B., Wu, H., Ott, H., Bennewitz, K., Wang, C., Poschet, G., Liu, H., Yuan, Z., Kroll, J., She, J. (2023) Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism. Journal of translational medicine. 21:199199
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Bláhová, Z., Franěk, R., Let, M., Bláha, M., Pšenička, M., Mráz, J. (2022) Partial fads2 Gene Knockout Diverts LC-PUFA Biosynthesis via an Alternative Δ8 Pathway with an Impact on the Reproduction of Female Zebrafish (Danio rerio). Genes. 13(4):
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
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