Gene
fabp7a
- ID
- ZDB-GENE-000627-1
- Name
- fatty acid binding protein 7, brain, a
- Symbol
- fabp7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gill; immature eye; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human FABP7 (fatty acid binding protein 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66373 (38 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fabp7a | Charlton-Perkins et al., 2019 | |
| CRISPR2-fabp7a | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein | Lipocalin/cytosolic fatty-acid binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q9I8N9 | InterPro | 132 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
fabp7a-203
(1)
|
Ensembl | 565 nt | ||
| mRNA |
fabp7a-201
(1)
|
Ensembl | 710 nt | ||
| mRNA |
fabp7a-202
(1)
|
Ensembl | 584 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fabp7a | monoclonal | Mouse |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp7a:DsRed) |
|
| 1 | Jin et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266G18 | ZFIN Curated Data | |
| Encodes | EST | fb62f07 | ||
| Encodes | EST | fq20b08 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:66373 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192112 | ZFIN Curated Data | |
| interacts with | Promoter | fabp7a_promoter | Laprairie et al., 2017 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131605 (1) | 700 nt | ||
| Genomic | GenBank:CU306817 (2) | 176617 nt | ||
| Polypeptide | UniProtKB:Q9I8N9 (1) | 132 aa |
- Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
- Mizoguchi, T., Okita, M., Minami, Y., Fukunaga, M., Maki, A., Itoh, M. (2023) Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon. Experimental gerontology. 178:112206
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Hsu, A.Y., Wang, T., Syahirah, R., Liu, S., Li, K., Zhang, W., Wang, J., Cao, Z., Tian, S., Matosevic, S., Staiger, C.J., Wan, J., Deng, Q. (2022) Rora Regulates Neutrophil Migration and Activation in Zebrafish. Frontiers in immunology. 13:756034
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Kouprianov, V.A., Selmek, A.A., Ferguson, J.L., Mo, X., Shive, H.R. (2022) brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury. Scientific Reports. 12:883
- Hung, J.C., Wu, J.L., Hong, J.R. (2021) Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Hung, J.C., Wu, J.L., Li, H.C., Chiu, H.W., Hong, J.R. (2021) The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish. Cells. 10(11):
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
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