Relation Results

Summary

Name DICER1/hAgo2/PRKRA
Primary ID SIGNOR-C41
Links CPX-1072
Type complex
Formed by AGO2, DICER1, PRKRA
Relations 4

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Type: Score: Layout: SPV 
0.8090.7620.70.893AGO2DICER1/hAgo2/PRKRAPRKRANcRNA_processingDICER1

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Relations
Regulator
Mechanism
target
score ℹ
+ AGO2form complex img/form-complex.png binding DICER1/hAgo2/PRKRA 0.809
Identifier Residue Sequence Organism Cell Line
SIGNOR-143102 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ PRKRAform complex img/form-complex.png binding DICER1/hAgo2/PRKRA 0.762
Identifier Residue Sequence Organism Cell Line
SIGNOR-255318 Homo sapiens
pmid sentence
Immunoprecipitation and reconstitution experiments in various systems have shown that Dicer associates with proteins in the Argonaute (Ago) family of endonucleases and with specific double-stranded RNA-binding proteins (dsRBPs) (3–7). | In humans, these dsRBPs are protein activator of PKR (PACT) (5) and trans-activation response RNA-binding protein (TRBP) (3,4).
Publications: 1 Organism: Homo Sapiens
+ DICER1/hAgo2/PRKRAup-regulates img/indirect-activation.png NcRNA_processing 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255322 Homo sapiens
pmid sentence
To test small RNA processing by such PACT-containing complexes, we tested the substrates described above for cleavage rates (pre-let-7a, pre-miR-34c and dsRNA W1) and product length specificity (pre-miR-200a and pre-miR-34c). The results of these experiments showed that Dicer–Ago2–TRBP and Dicer–Ago2–PACT produce the same miRNA products from pre-miR-200a and pre-miR-34c substrates as observed for Dicer–TRBP and Dicer–PACT, respectively (Figure 3A).
Publications: 1 Organism: Homo Sapiens
+ DICER1form complex img/form-complex.png binding DICER1/hAgo2/PRKRA 0.893
Identifier Residue Sequence Organism Cell Line
SIGNOR-143105 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
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