Personal information

Websites & social links

http://www.uniprot.org/
http://www.sib.swiss/

Keywords

Biocuration, Database, Swiss-Prot, UniProt, Bioinformatics, Biology

Countries

Switzerland

Activities

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Employment (4)

Swiss Institute of Bioinformatics Geneva: Geneva, GE, CH

2018-01-01 to present | Head of quality assurance program (Swiss-Prot)
Employment
Source: Self-asserted source
Sylvain Poux

Swiss Institute of Bioinformatics: Geneva, GE, CH

2009 to 2017-12-31 | Head of Annotation Department (Swiss-Prot)
Employment
Source: Self-asserted source
Sylvain Poux

Swiss Institute of Bioinformatics: Geneva, GE, CH

2006 to 2009 | Head of quality assurance program (Swiss-Prot)
Employment
Source: Self-asserted source
Sylvain Poux

Swiss Institute of Bioinformatics: Geneva, GE, CH

2001 to 2006 | Biocurator (Swiss-Prot)
Employment
Source: Self-asserted source
Sylvain Poux

Education and qualifications (3)

Universite de Geneve: Geneva, GE, CH

1996 to 2001 | Ph.D (Biology)
Education
Source: Self-asserted source
Sylvain Poux

Universite de Geneve: Geneva, GE, CH

1994 to 1996 | Master of Science (Biology)
Education
Source: Self-asserted source
Sylvain Poux

Universite de Geneve: Geneva, GE, CH

1990 to 1994 | Bachelor of Science (Biology)
Education
Source: Self-asserted source
Sylvain Poux

Professional activities (1)

ISB International Society for Biocuration: Geneva, CH

2014-12-01 to present | Executive committee
Membership
Source: Self-asserted source
Sylvain Poux

Works (49)

A compendium of human gene functions derived from evolutionary modelling.

Nature
2025-02-26 | Journal article
DOI: 10.1038/s41586-025-08592-0
PMID: 40011791
PMC: PMC11964926
Contributors: Marc Feuermann; Mi H; Pascale Gaudet; Anushya Muruganujan; Suzanna Lewis; Dustin Ebert; Mushayahama T; Gene Ontology Consortium; Paul D. Thomas
Source: Self-asserted source
Sylvain Poux

UniProt: the Universal Protein Knowledgebase in 2025.

Nucleic acids research
2025-01-01 | Journal article
DOI: 10.1093/nar/gkae1010
PMID: 39552041
PMC: PMC11701636
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux

EnzChemRED, a rich enzyme chemistry relation extraction dataset.

Scientific data
2024-09-09 | Journal article | Author
DOI: 10.1038/s41597-024-03835-7
PMID: 39251610
PMC: PMC11384730
Contributors: Po-Ting Lai; Elisabeth Coudert; Lucila Aimo; Kristian B. Axelsen; Lionel Breuza; Edouard de Castro; Marc Feuermann; Anne Morgat; Lucille Pourcel; Ivo Pedruzzi et al.
Source: Self-asserted source
Sylvain Poux

Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB.

Metabolites
2021-01-12 | Journal article
DOI: 10.3390/metabo11010048
PMID: 33445429
PMC: PMC7827101
Contributors: Marc Feuermann; emmanuel boutet; Anne Morgat; Kristian B. Axelsen; Bansal P; Jerven Bolleman; de Castro E; Coudert E; Gasteiger E; Géhant S et al.
Source: Self-asserted source
Sylvain Poux

Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns.

Open biology
2020-09-02 | Journal article
DOI: 10.1098/rsob.200149
PMID: 32875947
PMC: PMC7536087
Contributors: Valerie Wood; Seth Carbon; Midori A. Harris; Lock A; Stacia R Engel; Hill DP; Van Auken K; Helen Attrill; Marc Feuermann; Pascale Gaudet et al.
Source: Self-asserted source
Sylvain Poux

A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.

Journal of Alzheimer's disease : JAD
2020-01-01 | Journal article
DOI: 10.3233/jad-200206
PMID: 32716361
PMC: PMC7592670
Contributors: Lionel Breuza; Arighi CN; Argoud-Puy G; Casals-Casas C; Anne Estreicher; Famiglietti ML; George Georghiou; Gos A; Gruaz-Gumowski N; Hinz U et al.
Source: Self-asserted source
Sylvain Poux

Enzyme annotation in UniProtKB using Rhea.

Bioinformatics (Oxford, England)
2019-11 | Journal article
DOI: 10.1093/bioinformatics/btz817
PMID: 31688925
Contributors: Morgat A; Lombardot T; Coudert E; Axelsen K; Neto TB; Gehant S; Bansal P; Bolleman J; Gasteiger E; de Castro E et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

FAIR adoption, assessment and challenges at UniProt.

Scientific data
2019-09-20 | Journal article
DOI: 10.1038/s41597-019-0180-9
PMID: 31541106
Source: Self-asserted source
Sylvain Poux

An enhanced workflow for variant interpretation in UniProtKB/Swiss-Prot improves consistency and reuse in ClinVar

Database
2019-01-01 | Journal article
DOI: 10.1093/database/baz040
Contributors: M L Famiglietti; A Estreicher; L Breuza; S Poux; N Redaschi; I Xenarios; A Bridge
Source: check_circle
Crossref

Annotation of gene product function from high-throughput studies using the Gene Ontology.

Database : the journal of biological databases and curation
2019-01-01 | Journal article
DOI: 10.1093/database/baz007
PMID: 30715275
PMC: PMC6355445
Source: Self-asserted source
Sylvain Poux

Best Practices in Manual Annotation with the Gene Ontology.

2017 | Journal article
PMID: 27812934
Contributors: Poux S; Gaudet P
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The ins and outs of eukaryotic viruses: Knowledge base and ontology of a viral infection.

2017 | Journal article
PMID: 28207819
Contributors: Hulo C; Masson P; de Castro E; Auchincloss AH; Foulger R; Poux S; Lomax J; Bougueleret L; Xenarios I; Le Mercier P
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

UniProt: the universal protein knowledgebase

Nucleic acids research
2017 | Journal article
DOI: 10.1093/nar/gkw1099
Source: Self-asserted source
Sylvain Poux

On expert curation and scalability: UniProtKB/Swiss-Prot as a case study.

Bioinformatics (Oxford, England)
2017-07 | Journal article
DOI: 10.1093/bioinformatics/btx439
PMID: 29036270
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central
grade
Preferred source (of 2)‎

Bacterial Virus Ontology; Coordinating across Databases.

2017-05 | Journal article
DOI: 10.3390/v9060126
PMID: 28545254
PMC: PMC5490803
Contributors: Hulo C; Masson P; Toussaint A; Osumi-Sutherland D; de Castro E; Auchincloss AH; Poux S; Bougueleret L; Xenarios I; Le Mercier P
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The UniProtKB guide to the human proteome.

2016 | Journal article
DOI: 10.1093/database/bav120
PMID: 26896845
PMC: PMC4761109
Contributors: Breuza L; Poux S; Estreicher A; Famiglietti ML; Magrane M; Tognolli M; Bridge A; Baratin D; Redaschi N; UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View.

2016 | Journal article
DOI: 10.1007/978-1-4939-3167-5_2
PMID: 26519399
Contributors: Boutet E; Lieberherr D; Tognolli M; Schneider M; Bansal P; Bridge AJ; Poux S; Bougueleret L; Xenarios I
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

On expert curation and sustainability: UniProtKB/Swiss-Prot as a case study

2016-12-14 | Preprint
DOI: 10.1101/094011
Contributors: Sylvain Poux; Cecilia N. Arighi; Michele Magrane; Alex Bateman; Chih-Hsuan Wei; Zhiyong Lu; Emmanuel Boutet; Hema Bye-A-Jee; Maria Livia Famiglietti; Bernd Roechert
Source: check_circle
Crossref

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases.

2016-01 | Journal article
DOI: 10.1093/nar/gkv1310
PMID: 26615188
PMC: PMC4702916
Contributors: SIB Swiss Institute of Bioinformatics Members
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Representing virus-host interactions and other multi-organism processes in the Gene Ontology.

2015 | Journal article
DOI: 10.1186/s12866-015-0481-x
PMID: 26215368
PMC: PMC4517558
Contributors: Foulger RE; Osumi-Sutherland D; McIntosh BK; Hulo C; Masson P; Poux S; Le Mercier P; Lomax J
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Confidence Information Ontology: a step towards a standard for asserting confidence in annotations.

2015 | Journal article
DOI: 10.1093/database/bav043
PMID: 25957950
PMC: PMC4425939
Contributors: Bastian FB; Chibucos MC; Gaudet P; Giglio M; Holliday GL; Huang H; Lewis SE; Niknejad A; Orchard S; Poux S et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Gene Ontology Consortium: going forward.

2015-01 | Journal article
DOI: 10.1093/nar/gku1179
PMID: 25428369
PMC: PMC4383973
Contributors: Gene Ontology Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

HAMAP in 2015: updates to the protein family classification and annotation system.

2015-01 | Journal article
DOI: 10.1093/nar/gku1002
PMID: 25348399
PMC: PMC4383873
Contributors: Pedruzzi I; Rivoire C; Auchincloss AH; Coudert E; Keller G; de Castro E; Baratin D; Cuche BA; Bougueleret L; Poux S et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

UniProt: a hub for protein information.

2015-01 | Journal article
DOI: 10.1093/nar/gku989
PMID: 25348405
PMC: PMC4384041
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

An integrated ontology resource to explore and study host-virus relationships.

2014 | Journal article
DOI: 10.1371/journal.pone.0108075
PMID: 25233094
PMC: PMC4169452
Contributors: Masson P; Hulo C; de Castro E; Foulger R; Poux S; Bridge A; Lomax J; Bougueleret L; Xenarios I; Le Mercier P
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data.

2014 | Journal article
DOI: 10.1093/database/bau016
PMID: 24622611
PMC: PMC3950660
Contributors: Poux S; Magrane M; Arighi CN; Bridge A; O'Donovan C; Laiho K; UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Genetic variations and diseases in UniProtKB/Swiss-Prot: the ins and outs of expert manual curation.

2014-08 | Journal article
DOI: 10.1002/humu.22594
PMID: 24848695
PMC: PMC4107114
Contributors: Famiglietti ML; Estreicher A; Gos A; Bolleman J; Géhant S; Breuza L; Bridge A; Poux S; Redaschi N; Bougueleret L et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Activities at the Universal Protein Resource (UniProt).

2014-01 | Journal article
DOI: 10.1093/nar/gkt1140
PMID: 24253303
PMC: PMC3965022
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Gene Ontology annotations and resources.

2013-01 | Journal article
DOI: 10.1093/nar/gks1050
PMID: 23161678
PMC: PMC3531070
Contributors: Gene Ontology Consortium; Blake JA; Dolan M; Drabkin H; Hill DP; Li N; Sitnikov D; Bridges S; Burgess S; Buza T et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

HAMAP in 2013, new developments in the protein family classification and annotation system.

2013-01 | Journal article
DOI: 10.1093/nar/gks1157
PMID: 23193261
PMC: PMC3531088
Contributors: Pedruzzi I; Rivoire C; Auchincloss AH; Coudert E; Keller G; de Castro E; Baratin D; Cuche BA; Bougueleret L; Poux S et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

UniProtKB amid the turmoil of plant proteomics research.

2012 | Journal article
DOI: 10.3389/fpls.2012.00270
PMID: 23230445
PMC: PMC3515866
Contributors: Schneider M; UniProt Consortium; Poux S
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The UniProtKB/Swiss-Prot Tox-Prot program: A central hub of integrated venom protein data.

2012-09 | Journal article
DOI: 10.1016/j.toxicon.2012.03.010
PMID: 22465017
PMC: PMC3393831
Contributors: Jungo F; Bougueleret L; Xenarios I; Poux S
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Reorganizing the protein space at the Universal Protein Resource (UniProt).

2012-01 | Journal article
DOI: 10.1093/nar/gkr981
PMID: 22102590
PMC: PMC3245120
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Gene Ontology: enhancements for 2011.

2012-01 | Journal article
DOI: 10.1093/nar/gkr1028
PMID: 22102568
PMC: PMC3245151
Contributors: Gene Ontology Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The UniProt-GO Annotation database in 2011.

2012-01 | Journal article
DOI: 10.1093/nar/gkr1048
PMID: 22123736
PMC: PMC3245010
Contributors: Dimmer EC; Huntley RP; Alam-Faruque Y; Sawford T; O'Donovan C; Martin MJ; Bely B; Browne P; Mun Chan W; Eberhardt R et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

UniProt Knowledgebase: a hub of integrated protein data.

2011 | Journal article
DOI: 10.1093/database/bar009
PMID: 21447597
PMC: PMC3070428
Contributors: Magrane M; UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Ongoing and future developments at the Universal Protein Resource.

2011-01 | Journal article
DOI: 10.1093/nar/gkq1020
PMID: 21051339
PMC: PMC3013648
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.

2010-04 | Journal article
DOI: 10.1007/s00018-009-0229-6
PMID: 20043185
PMC: PMC2835715
Contributors: Hinz U; UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Gene Ontology in 2010: extensions and refinements.

2010-01 | Journal article
DOI: 10.1093/nar/gkp1018
PMID: 19920128
PMC: PMC2808930
Contributors: Gene Ontology Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Universal Protein Resource (UniProt) in 2010.

2010-01 | Journal article
DOI: 10.1093/nar/gkp846
PMID: 19843607
PMC: PMC2808944
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Collaborative annotation of genes and proteins between UniProtKB/Swiss-Prot and dictyBase.

2009 | Journal article
DOI: 10.1093/database/bap016
PMID: 20157489
PMC: PMC2790310
Contributors: Gaudet P; Lane L; Fey P; Bridge A; Poux S; Auchincloss A; Axelsen K; Braconi Quintaje S; Boutet E; Brown P et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Universal Protein Resource (UniProt) 2009.

2009-01 | Journal article
DOI: 10.1093/nar/gkn664
PMID: 18836194
PMC: PMC2686606
Contributors: UniProt Consortium
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.

2004-02 | Journal article
DOI: 10.1038/nbt926
PMID: 14755292
Contributors: Hermjakob H; Montecchi-Palazzi L; Bader G; Wojcik J; Salwinski L; Ceol A; Moore S; Orchard S; Sarkans U; von Mering C et al.
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Assembly of Polycomb complexes and silencing mechanisms.

2003-03 | Journal article
DOI: 10.1023/A:1022992011833
PMID: 12723698
Contributors: Pirrotta V; Poux S; Melfi R; Pilyugin M
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing.

2002-05 | Journal article
PMID: 11973279
Contributors: Poux S; Horard B; Sigrist CJ; Pirrotta V
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Establishment of Polycomb silencing requires a transient interaction between PC and ESC.

2001-10 | Journal article
DOI: 10.1101/gad.208901
PMID: 11581156
PMC: PMC312795
Contributors: Poux S; Melfi R; Pirrotta V
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Recruitment of components of Polycomb Group chromatin complexes in Drosophila.

2001-01 | Journal article
PMID: 11092813
Contributors: Poux S; McCabe D; Pirrotta V
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor.

2000-05 | Journal article
DOI: 10.1128/MCB.20.9.3187-3197.2000
PMID: 10757803
PMC: PMC85613
Contributors: Horard B; Tatout C; Poux S; Pirrotta V
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element.

1996-09 | Journal article
PMID: 8887562
PMC: PMC452203
Contributors: Poux S; Kostic C; Pirrotta V
Source: Self-asserted source
Sylvain Poux via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for F1000Research. (1)
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