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NEP nonstructural protein 2 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 956532, updated on 6-Oct-2023

Summary

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Gene symbol
NEP
Gene description
nonstructural protein 2
Locus tag
FLUAVs8gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
Also known as
NS2
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Genomic context

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Location:
segment: 8
Sequence:
NC_002020.1 (27..864)

NC_002020.1Genomic Context describing neighboring genes Neighboring gene nonstructural protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002020.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary characterization of the pandemic H1N1/2009 influenza virus in humans based on non-structural genes. Wang C, et al. PLoS One, 2013. PMID 23418535, Free PMC Article
  2. A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins. Huang S, et al. J Virol, 2013 Jan. PMID 23115280, Free PMC Article
  3. Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP. Shimizu T, et al. FEBS Lett, 2011 Jan 3. PMID 21081124
  4. Complete nucleotide sequence of the influenza A/PR/8/34 virus NS gene and comparison with the NS genes of the A/Udorn/72 and A/FPV/Rostock/34 strains. Baez M, et al. Nucleic Acids Res, 1980 Dec 11. PMID 7465426, Free PMC Article
  5. Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses. Hall RM, et al. J Virol, 1981 Apr. PMID 7241645, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NS1- and NS2-interacting proteins.
    Title: Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor.
  2. Data indicate that the NS2 gene showed positive selection pressure in April and August of 2009.
    Title: Evolutionary characterization of the pandemic H1N1/2009 influenza virus in humans based on non-structural genes.
  3. The interaction between NS2 and CRM1 is coordinately regulated by both the previously reported nuclear export signal (NES1) and now the new NES2.
    Title: A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins.
  4. Data demonstrate that the C-terminal domain of NS2 (residues 81-100) is essential for M1 binding and the nuclear export of progeny vRNPs.
    Title: Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
nonstructural protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002020.1 Reference assembly

    Range
    27..864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040983.1 nonstructural protein 2 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for NP_040983.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17043, Q76MT9
    UniProtKB/TrEMBL
    A0A2R4QPM7, A0A343VTQ5, A4ZNQ2, C3PQG1, C3PQH2, C4LP15, F0TTJ4, F0TTS1, F0TU42, F0TU64, F5CGM7, F5CGN8, F5CGP9, H2KIX7, H2KIZ7, H8PHK6, H8XZT0, H8XZV4, H8XZW4, H8XZX4, I6S6D8, I6S742, I6S8Z6, I6T2Y2, I6T375, I6T3P8, I6TAF8, I6TDU8, I6TEK6, J7GRB1, M9V1B9, R9WJP6, R9WKI0, S5FRD0, S5FSF7, S5G2N6
    Conserved Domains (1) summary
    pfam00601
    Location:28 → 121
    Flu_NS2; Influenza non-structural protein (NS2)
Nucleotide Protein
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