CCL1 TFIIH complex kinase subunit CCL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: CCL1
Gene description: TFIIH complex kinase subunit CCL1
Primary source: SGD:S000006229
Locus tag: YPR025C
See related: AllianceGenome:SGD:S000006229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including cellular response to nitrogen starvation; phosphorylation of RNA polymerase II C-terminal domain; and positive regulation of Atg1/ULK1 kinase complex assembly. Located in mitochondrion. Part of transcription factor TFIIK complex. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Atg1/ULK1 kinase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIK complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info

NP_015350.1

Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly; human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature