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TAF9 chromatin modification protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 855276, updated on 13-Apr-2024

Summary

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Gene symbol
TAF9
Gene description
chromatin modification protein
Primary source
SGD:S000004849
Locus tag
YMR236W
See related
AllianceGenome:SGD:S000004849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TAF17
Summary
Enables chromatin binding activity and molecular adaptor activity. Involved in RNA polymerase II preinitiation complex assembly; chromatin organization; and histone acetylation. Part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to human TAF9 (TATA-box binding protein associated factor 9) and TAF9B (TATA-box binding protein associated factor 9b). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (742971..743444)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene RNA-DNA hybrid ribonuclease Neighboring gene GTPase-activating protein RNA1 Neighboring gene exomer complex subunit Neighboring gene putative mannan endo-1,6-alpha-mannosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. Apone LM, et al. Mol Cell, 1998 Nov. PMID 9844637
  2. A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription. Macpherson N, et al. Genetics, 2000 Apr. PMID 10747053, Free PMC Article
  3. Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Keaveney M, et al. Mol Cell, 1998 May. PMID 9660975
  4. A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Selleck W, et al. Nat Struct Biol, 2001 Aug. PMID 11473260
  5. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Brown CE, et al. Science, 2001 Jun 22. PMID 11423663

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest a crucial role for the Taf9 C-terminal conserved region domain in genome-wide transcription and highlight the importance of conserved domains, other than histone fold domains, as a common determinant for TFIID and SAGA functions.
    Title: The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.
  2. May have role in transcription elongation, and may be involved in cell cycle and growth control.
    Title: TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromatin modification protein
NP_013963.1
  • Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    742971..743444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182743.1 → NP_013963.1  TPA: chromatin modification protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013963.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W062, Q05027
    UniProtKB/TrEMBL
    A0A6A5PQS2, A6ZMU9, B3LMC5, C7GRB5, C8ZFA1, G2WKU4, N1NZ24
    Conserved Domains (1) summary
    COG5094
    Location:1 → 157
    TAF9; Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6T9I_F.1
6T9K_F.1
Q05027.1

Gene LinkOut

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