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TAF13 Taf13p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854875, updated on 13-Apr-2024

Summary

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Gene symbol
TAF13
Gene description
Taf13p
Primary source
SGD:S000004564
Locus tag
YML098W
See related
AllianceGenome:SGD:S000004564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN81; TAF19
Summary
Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly. Located in nucleus. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (77267..77770)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene trehalose 6-phosphate synthase/phosphatase complex subunit Neighboring gene Arg81p Neighboring gene guanine nucleotide exchange factor VPS9 Neighboring gene putative asparagine synthase Neighboring gene DNA repair protein RAD10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of two new genes essential for vegetative growth in Saccharomyces cerevisiae: nucleotide sequence determination and chromosome mapping. Dubois E, et al. Gene, 1987. PMID 3311883
  2. TFIID-specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivo. Komarnitsky PB, et al. Genes Dev, 1999 Oct 1. PMID 10521393, Free PMC Article
  3. Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7. Gangloff YG, et al. Mol Cell Biol, 2001 Mar. PMID 11238921, Free PMC Article
  4. The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit. Lemaire M, et al. J Biol Chem, 2000 Sep 1. PMID 10864925
  5. Yeast homologues of higher eukaryotic TFIID subunits. Moqtaderi Z, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962109, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IC
Inferred by Curator
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Taf13p
NP_013611.1
  • TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    77267..77770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182458.1 → NP_013611.1  TPA: Taf13p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0I7, P11747
    UniProtKB/TrEMBL
    A0A8H4F9E4, C7GV80, G2WJV9
    Conserved Domains (1) summary
    COG5248
    Location:1 → 133
    TAF19; Transcription initiation factor TFIID, subunit TAF13 [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11747.2

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