Mterf1 mitochondrial transcription termination factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mterf1provided by RGD
Official Full Name: mitochondrial transcription termination factor 1provided by RGD
Primary source: RGD:621318
See related: Ensembl:ENSRNOG00000007899 AllianceGenome:RGD:621318
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mterf
Summary: Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA geometric change and termination of mitochondrial transcription. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 117.4), Thymus (RPKM 111.9) and 9 other tissues See more
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Genomic context

Location:: 4q13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (31181048..31188130)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (30226345..30233402)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (27365310..27372374)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The DNA-binding activity of mTERF is unaffected by the phosphorylation or dephosphorylation state, however, only the phosphorylated form of the protein is active for termination activity.
Title: Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA geometric change	ISO Inferred from Sequence Orthology more info
involved_in DNA geometric change	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated transcription termination	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription termination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in termination of mitochondrial transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in termination of mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in termination of mitochondrial transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription termination factor 1, mitochondrial

Names: transcription termination factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053499.1 → NP_445951.1 transcription termination factor 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_445951.1

Status: PROVISIONAL

Source sequence(s)

AJ292524

UniProtKB/Swiss-Prot

Q9EPI8

Conserved Domains (1) summary

pfam02536
Location:53 → 366

mTERF; mTERF