Ptger2 prostaglandin E receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptger2provided by RGD
Official Full Name: prostaglandin E receptor 2provided by RGD
Primary source: RGD:620020
See related: Ensembl:ENSRNOG00000050968 AllianceGenome:RGD:620020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EP2; Ptger-ep2
Summary: Enables prostaglandin E receptor activity. Involved in positive regulation of gastric mucosal blood circulation. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 19.1), Lung (RPKM 12.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (20694765..20708475)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (18215013..18228714)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (19336029..19349759)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Title: Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Title: Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
the involvement of prostaglandin signaling from mesenchymal stem cells in dopaminergic neuron survival through EP2 receptors, is reported.
Title: Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.
EP2 contributes to generating mechanical hyperalgesia through positive feedback upregulation of COX-2 expression in muscle after lengthening contractions
Title: EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions.
These results indicate that EP2 activation, which initially promotes microglial activation, later causes delayed death of activated microglia, potentially contributing to the resolution phase of neuroinflammation.
Title: EP2 Receptor Signaling Regulates Microglia Death.
EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression.
Title: Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
In the spinal cord 1 day after painful joint injury there is increased expression of prostaglandin E2 receptor.
Title: Increased interleukin-1α and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation.
Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus.
Title: Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling.
Data indicate that painful cervical facet joint distraction induces an immediate and sustained increase of prostaglandin E2 (PGE2) receptor EP2 expression in the dorsal root ganglion (DRG).
Title: The prostaglandin E2 receptor, EP2, is upregulated in the dorsal root ganglion after painful cervical facet joint injury in the rat.
EP2 receptor signaling pathways regulate classical activation of microglia
Title: EP2 receptor signaling pathways regulate classical activation of microglia.

Submit: New GeneRIF Correction See all GeneRIFs (27)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gastric mucosal blood circulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP2 subtype

Names: PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2); prostaglandin E receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype-like; prostaglandin E2 receptor type 2; prostanoid EP2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031088.2 → NP_112350.1 prostaglandin E2 receptor EP2 subtype

See identical proteins and their annotated locations for NP_112350.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q547S0, Q62928

UniProtKB/TrEMBL

A6KDY9

Related

ENSRNOP00000064907.1, ENSRNOT00000075209.3

Conserved Domains (1) summary

pfam00001
Location:39 → 314

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

20694765..20708475

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093687.2 → XP_038949615.1 prostaglandin E2 receptor EP2 subtype isoform X1

Conserved Domains (2) summary

cd14964
Location:24 → 50

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:24 → 281

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily