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Gnb2 G protein subunit beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81667, updated on 11-Apr-2024

Summary

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Official Symbol
Gnb2provided by RGD
Official Full Name
G protein subunit beta 2provided by RGD
Primary source
RGD:69319
See related
Ensembl:ENSRNOG00000001409 AllianceGenome:RGD:69319
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg2c1
Summary
Enables calcium channel regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell body. Part of protein-containing complex. Orthologous to human GNB2 (G protein subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 302.8), Spleen (RPKM 292.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24795505..24800796)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19159002..19164021)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22229079..22234096)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene actin-like 6B Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene POP7 homolog, ribonuclease P/MRP subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma. Sharma SK, et al. Indian J Biochem Biophys, 2002 Jun. PMID 22905384
  2. Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons. Hernández-Castellanos JM, et al. Biochem Biophys Res Commun, 2014 Feb 28. PMID 24513289
  3. Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons. Mahmoud S, et al. J Physiol, 2012 Oct 1. PMID 22711958, Free PMC Article
  4. Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms. Arnot MI, et al. J Physiol, 2000 Sep 1. PMID 10970423, Free PMC Article
  5. Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release. Zhang XL, et al. PLoS One, 2011. PMID 21633701, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that verexpression of Gbeta2 subunit mimics CaV2.2 kinetic slowing by noradrenaline.
    Title: Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.
  2. Gnb2 and Gnb4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons
    Title: Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons.
  3. analysis of enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma
    Title: Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
  4. Data show that the C-terminus of SNAP-25 is a binding target for Gbetagamma necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD.
    Title: Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Names
g protein subunit beta-2
guanine nucleotide binding protein (G protein), beta 2
guanine nucleotide binding protein (G protein), beta polypeptide 2
guanine nucleotide binding protein beta 2 subunit
guanine nucleotide binding protein, beta polypeptide 2
guanine nucleotide-binding protein, beta 2
heterotrimeric guanine nucleotide-binding protein 2c1
transducin beta chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031037.2 → NP_112299.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

    See identical proteins and their annotated locations for NP_112299.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065579
    UniProtKB/Swiss-Prot
    P54313, Q71SU9
    UniProtKB/TrEMBL
    A6J023, Q45QL6
    Related
    ENSRNOP00000001911.3, ENSRNOT00000001911.5
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24795505..24800796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271695.1 → XP_063127765.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    P54313, Q71SU9
    UniProtKB/TrEMBL
    A6J023

  2. XM_039089800.2 → XP_038945728.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    P54313, Q71SU9
    UniProtKB/TrEMBL
    A6J023, Q45QL6
    Related
    ENSRNOP00000079960.1
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  3. XM_039089799.2 → XP_038945727.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    P54313, Q71SU9
    UniProtKB/TrEMBL
    A6J023, Q45QL6
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]

  4. XM_039089801.2 → XP_038945729.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    P54313, Q71SU9
    UniProtKB/TrEMBL
    A6J023, Q45QL6
    Conserved Domains (2) summary
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54313.4 GenPept UniProtKB/Swiss-Prot:P54313

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