mef2cb myocyte enhancer factor 2cb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mef2cbprovided by ZNC
Official Full Name: myocyte enhancer factor 2cbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040901-7
See related: Ensembl:ENSDARG00000009418 AllianceGenome:ZFIN:ZDB-GENE-040901-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-202e12.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Acts upstream of or within heart development and transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including bone element; brain; cardiovascular system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (48181004..48307767, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (47529493..47656264, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour.
Title: mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour.
Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle.
Title: Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle.
Mef2 controls skeletal muscle formation after terminal differentiation.
Title: Mef2s are required for thick filament formation in nascent muscle fibres.
Mef2cbL contains an evolutionarily conserved domain derived from exonization of a fragment of intron 5, which confers the ability to induce ectopic muscle in mesoderm upon over-expression of the protein.
Title: Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb.
Mef2ca single mutants have delayed heart development, but form an apparently normal heart. Mef2cb single mutants have a functional heart and are viable adults.
Title: Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation.
Data show that mef2cb is expressed in the late ventricular region, and is necessary for late myocardial addition to the arterial pole.
Title: Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myocyte enhancer factor 2cb; myocyte-specific enhancer factor 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130962.1 → NP_001124434.1 myocyte enhancer factor 2cb

See identical proteins and their annotated locations for NP_001124434.1

Status: PROVISIONAL

Source sequence(s)

EU825718

UniProtKB/TrEMBL

B5A8L9

Related

ENSDARP00000044082.6, ENSDART00000044083.6

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

48181004..48307767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356177.2 → XP_017211666.1 myocyte-specific enhancer factor 2C isoform X2

UniProtKB/TrEMBL

A0A8M6Z6Z1

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 148

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_017356179.2 → XP_017211668.1 myocyte-specific enhancer factor 2C isoform X4

UniProtKB/TrEMBL

A0A8M6Z6E2, A2BGA7

Related

ENSDARP00000114315.1, ENSDART00000135911.3

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_009301758.3 → XP_009300033.1 myocyte-specific enhancer factor 2C isoform X1

See identical proteins and their annotated locations for XP_009300033.1

UniProtKB/TrEMBL

A0A0R4ITE5, A0A8M3B2S1

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_009301763.3 → XP_009300038.1 myocyte-specific enhancer factor 2C isoform X7

UniProtKB/TrEMBL

A0A8M3ASM1

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 148

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_009301764.3 → XP_009300039.1 myocyte-specific enhancer factor 2C isoform X8

UniProtKB/TrEMBL

A0A8M3B9V7

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:127 → 168

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_009301765.3 → XP_009300040.1 myocyte-specific enhancer factor 2C isoform X9

UniProtKB/TrEMBL

A0A8M3ASR6

Conserved Domains (3) summary

COG5068
Location:1 → 265

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 148

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_009301757.3 → XP_009300032.1 myocyte-specific enhancer factor 2C isoform X1

See identical proteins and their annotated locations for XP_009300032.1

UniProtKB/TrEMBL

A0A0R4ITE5, A0A8M3B2S1

Related

ENSDARP00000138296.2, ENSDART00000163250.2

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_017356180.2 → XP_017211669.1 myocyte-specific enhancer factor 2C isoform X5

UniProtKB/TrEMBL

A0A2R8QP40, A0A8M6YZ69

Related

ENSDARP00000157387.1, ENSDART00000183585.1

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 148

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_017356181.2 → XP_017211670.1 myocyte-specific enhancer factor 2C isoform X6

UniProtKB/TrEMBL

A0A8M6Z0P2

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_017356178.2 → XP_017211667.1 myocyte-specific enhancer factor 2C isoform X3

UniProtKB/TrEMBL

A0A8M6YYB3, F1QNL1

Related

ENSDARP00000154164.1, ENSDART00000182831.1

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...