cyp27b1 cytochrome P450, family 27, subfamily B, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp27b1provided by ZNC
Official Full Name: cytochrome P450, family 27, subfamily B, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-111005-2
See related: Ensembl:ENSDARG00000045015 AllianceGenome:ZFIN:ZDB-GENE-111005-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables calcidiol 1-monooxygenase activity. Acts upstream of or within hematopoietic stem cell proliferation. Is expressed in heart; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (329764..339747)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (303266..313249)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
Title: Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcidiol 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcitriol biosynthetic process from calciol	IDA Inferred from Direct Assay more info	PubMed
involved_in calcitriol biosynthetic process from calciol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Names: 25-hydroxyvitamin D-1alpha-hydroxylase

NP_001298720.1

EC 1.14.15.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311791.1 → NP_001298720.1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Status: PROVISIONAL

Source sequence(s)

KM262796

UniProtKB/TrEMBL

A0A097HUX0

Related

ENSDARP00000142417.1, ENSDART00000172882.2

Conserved Domains (1) summary

pfam00067
Location:45 → 493

p450; Cytochrome P450