qdprb.1 quinoid dihydropteridine reductase b, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: qdprb.1provided by ZNC
Official Full Name: quinoid dihydropteridine reductase b, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-320
See related: Ensembl:ENSDARG00000037378 AllianceGenome:ZFIN:ZDB-GENE-050522-320
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: qdprb1; wu:fj24b09; zgc:101857; zgc:112405; si:dkey-92j12.1
Summary: Enables 6,7-dihydropteridine reductase activity. Acts upstream of or within brain development; gliogenesis; and glutamine metabolic process. Predicted to be active in cytoplasm. Is expressed in ciliary marginal zone; eye; midbrain hindbrain boundary; optic tectum; and retina. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (22845306..22851454, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22154567..22160715, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 6,7-dihydropteridine reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6,7-dihydropteridine reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables 6,7-dihydropteridine reductase activity	IEA Inferred from Electronic Annotation more info
enables NADH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dihydropteridine reductase

Names: dihydropteridine reductase Ba; quinoid dihydropteridine reductase b1

NP_001018534.1

EC 1.5.1.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020698.1 → NP_001018534.1 dihydropteridine reductase

See identical proteins and their annotated locations for NP_001018534.1

Status: PROVISIONAL

Source sequence(s)

BC095805

UniProtKB/TrEMBL

A0A2R8QEV6, B2GRK5, Q501Z2, Q66IB5

Related

ENSDARP00000054385.4, ENSDART00000054386.5

Conserved Domains (2) summary

cd05334
Location:6 → 228

DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs

PRK12828
Location:5 → 224

PRK12828; short chain dehydrogenase; Provisional