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ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Bos taurus (cattle) ]

Gene ID: 785911, updated on 3-Apr-2024

Summary

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Official Symbol
ROCK1provided by VGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 1provided by VGNC
Primary source
VGNC:VGNC:56371
See related
BGD:BT22527; Ensembl:ENSBTAG00000008403
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ROCK-I; p160ROCK
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (35015582..35140283)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene GREB1 like retinoic acid receptor coactivator Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized protein MGC133647 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene ubiquitin specific peptidase 14 Neighboring gene microRNA mir-544b-2 Neighboring gene THO complex subunit 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rho-GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via myosin light chain phosphorylation and cofilin phosphorylation. Lee SR, et al. Mol Reprod Dev, 2015 Nov. PMID 26175189
  2. ROCK1 translocates from non-caveolar to caveolar regions upon KCl stimulation in airway smooth muscle. Sommer B, et al. Physiol Res, 2014. PMID 24397803
  3. RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC). Chen NX, et al. Am J Physiol Renal Physiol, 2010 Sep. PMID 20610533, Free PMC Article
  4. Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. Shimizu T, et al. J Biol Chem, 2003 Nov 14. PMID 12954645
  5. Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants. Nakagawa K, et al. Inflamm Res, 2012 Oct. PMID 22688963

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK/cofilin pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
    Title: The Rho-GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via myosin light chain phosphorylation and cofilin phosphorylation.
  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
    Title: ROCK1 translocates from non-caveolar to caveolar regions upon KCl stimulation in airway smooth muscle.
  3. p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
    Title: Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants.
  4. The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
    Title: RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC).
  5. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa vasorum endothelial cells, is reported.
    Title: PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.
  6. These results suggest the existence of a feedback loop between cytoskeletal tension, adhesion maturation, and ROCK signaling that likely contributes to numerous mechanochemical processes.[ROCK]
    Title: Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension.
  7. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
    Title: Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 1
Names
p160 ROCK-1
rho-associated, coiled-coil-containing protein kinase 1
rho-associated, coiled-coil-containing protein kinase I
XP_002697835.5
XP_024840328.1
XP_059737020.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    35015582..35140283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002697789.7 → XP_002697835.5  rho-associated protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1ND05, F1MF50
    Related
    ENSBTAP00000053818.4, ENSBTAT00000061061.4
    Conserved Domains (5) summary
    smart00109
    Location:1229 → 1283
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd11639
    Location:489 → 554
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    cd01242
    Location:1119 → 1225
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2 → 406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
    cl25732
    Location:450 → 1097
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_024984560.2 → XP_024840328.1  rho-associated protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    F1MF50
    Conserved Domains (5) summary
    smart00109
    Location:1228 → 1282
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd11639
    Location:488 → 553
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    cd01242
    Location:1118 → 1224
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2 → 406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
    cl25732
    Location:420 → 1096
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_059881037.1 → XP_059737020.1  rho-associated protein kinase 1 isoform X3

    Related
    ENSBTAP00000065200.2, ENSBTAT00000087420.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191227.1: Suppressed sequence

    Description
    NM_001191227.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MIT6.1 GenPept UniProtKB/Swiss-Prot:Q8MIT6

Gene LinkOut

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