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Ehmt1 euchromatic histone methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 77683, updated on 28-Apr-2024

Summary

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Official Symbol
Ehmt1provided by MGI
Official Full Name
euchromatic histone methyltransferase 1provided by MGI
Primary source
MGI:MGI:1924933
See related
Ensembl:ENSMUSG00000036893 AllianceGenome:MGI:1924933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik
Summary
Enables C2H2 zinc finger domain binding activity; histone methyltransferase activity (H3-K27 specific); and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.6), whole brain E14.5 (RPKM 23.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 16.73 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24680781..24809658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24790769..24919643, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND domain containing 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis. Demond H, et al. Genome Res, 2023 Jan. PMID 36690445, Free PMC Article
  2. GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development. You L, et al. J Biochem Mol Toxicol, 2023 Feb. PMID 36424357
  3. EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas. Negwer M, et al. Brain Struct Funct, 2020 Dec. PMID 32975655, Free PMC Article
  4. The Object Space Task reveals increased expression of cumulative memory in a mouse model of Kleefstra syndrome. Schut EHS, et al. Neurobiol Learn Mem, 2020 Sep. PMID 32531423
  5. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Frega M, et al. Cell Rep, 2020 Jan 7. PMID 31914384

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development.
    Title: GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development.
  2. Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis.
    Title: Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis.
  3. Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFkappaB p50 recruitment.
    Title: Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment.
  4. The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.
    Title: The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.
  5. EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.
    Title: EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.
  6. Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.
    Title: Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.
  7. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
    Title: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
  8. transcription factor Wiz recruits the histone methyltransferase Ehmt1 to Foxp3 Treg-specific demethylated regions.
    Title: Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells.
  9. the regulation of NRF1 transcriptional activity by CDK2 may allow the modulation of Ehmt1 expression, therefore controlling the dynamic methylation of H3K9 during meiotic prophase.
    Title: CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.
  10. Primary cultures of cortical neuronal networks derived from Ehmt1+/- mice showed network bursts with lower frequency and longer duration compared to cultures from littermate controls. NMDAR/AMPAR ratio was significantly increased in cortical networks of Ehmt1+/- mice, due to increased NMDAR activity.
    Title: Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Transgenic (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA methylation-dependent heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-lysine dimethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine dimethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-lysine dimethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine monomethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EHMT1
Names
G9a-like protein 1
euchromatic histone-lysine N-methyltransferase 1
lysine N-methyltransferase 1D
NP_001012536.2
NP_001103156.1
NP_001103157.1
NP_766133.2
XP_006498485.1
XP_006498486.1
XP_006498487.1
XP_006498488.1
XP_006498489.1
XP_006498493.1
XP_006498494.1
XP_006498495.1
XP_017174824.1
XP_017174825.1
XP_030108067.1
XP_030108068.1
XP_030108069.1
XP_030108070.1
XP_030108071.1
XP_030108072.1
XP_030108073.1
XP_030108074.1
XP_030108075.1
XP_030108076.1
XP_030108077.1
XP_030108078.1
XP_030108079.1
XP_030108081.1
XP_030108082.1
XP_030108083.1
XP_030108084.1
XP_030108085.1
XP_030108086.1
XP_030108087.1
XP_030108088.1
XP_030108089.1
XP_030108090.1
XP_030108091.1
XP_036018604.1
XP_036018605.1
XP_036018606.1
XP_036018608.1
XP_036018609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012518.3 → NP_001012536.2  histone-lysine N-methyltransferase EHMT1 isoform 1

    See identical proteins and their annotated locations for NP_001012536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL732525, BB621957, BC089302, DV649682
    Consensus CDS
    CCDS15740.1
    UniProtKB/Swiss-Prot
    A2AIS3, A2AIS4, Q5DW34, Q5EBR1, Q6PGM0
    UniProtKB/TrEMBL
    Z4YJZ7
    Related
    ENSMUSP00000119057.3, ENSMUST00000147147.8
    Conserved Domains (6) summary
    smart00248
    Location:772 → 798
    ANK; ankyrin repeats
    smart00317
    Location:1124 → 1246
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:798 → 924
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05033
    Location:1012 → 1116
    Pre-SET; Pre-SET motif
    pfam12796
    Location:808 → 901
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:803 → 834
    ANK; ANK repeat [structural motif]

  2. NM_001109686.2 → NP_001103156.1  histone-lysine N-methyltransferase EHMT1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL732525, BB621957, BC089302, DV649682
    Consensus CDS
    CCDS59634.1
    UniProtKB/TrEMBL
    Z4YJZ7
    Related
    ENSMUSP00000110075.3, ENSMUST00000114432.9
    Conserved Domains (6) summary
    smart00248
    Location:719 → 745
    ANK; ankyrin repeats
    smart00317
    Location:1071 → 1193
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:745 → 871
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05033
    Location:959 → 1063
    Pre-SET; Pre-SET motif
    pfam12796
    Location:755 → 848
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:750 → 781
    ANK; ANK repeat [structural motif]

  3. NM_001109687.2 → NP_001103157.1  histone-lysine N-methyltransferase EHMT1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL732525, BB621957, BC056938, DV649682
    Consensus CDS
    CCDS59636.1
    UniProtKB/TrEMBL
    E9Q5A3
    Related
    ENSMUSP00000046077.6, ENSMUST00000046227.12
    Conserved Domains (6) summary
    smart00248
    Location:724 → 750
    ANK; ankyrin repeats
    smart00317
    Location:1076 → 1198
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:750 → 876
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05033
    Location:964 → 1068
    Pre-SET; Pre-SET motif
    pfam12796
    Location:760 → 853
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:755 → 786
    ANK; ANK repeat [structural motif]

  4. NM_172545.4 → NP_766133.2  histone-lysine N-methyltransferase EHMT1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK049454, AK086833, AL732525, BB621957, DV649682
    Consensus CDS
    CCDS59635.1
    UniProtKB/TrEMBL
    A0A0H2UH19, Z4YJZ7
    Related
    ENSMUSP00000100002.5, ENSMUST00000102938.10
    Conserved Domains (6) summary
    smart00248
    Location:765 → 791
    ANK; ankyrin repeats
    smart00317
    Location:1117 → 1239
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:791 → 917
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05033
    Location:1005 → 1109
    Pre-SET; Pre-SET motif
    pfam12796
    Location:801 → 894
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:796 → 827
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24680781..24809658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252227.2 → XP_030108087.1  histone-lysine N-methyltransferase EHMT1 isoform X34

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:695 → 921
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:746 → 777
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:751 → 844
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:977 → 1207
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  2. XM_030252218.2 → XP_030108078.1  histone-lysine N-methyltransferase EHMT1 isoform X23

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:712 → 938
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:763 → 794
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:768 → 861
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:994 → 1224
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  3. XM_030252223.2 → XP_030108083.1  histone-lysine N-methyltransferase EHMT1 isoform X27

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:710 → 936
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:761 → 792
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:766 → 859
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:992 → 1222
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  4. XM_030252210.2 → XP_030108070.1  histone-lysine N-methyltransferase EHMT1 isoform X9

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:758 → 984
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:809 → 840
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:814 → 907
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1040 → 1270
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  5. XM_030252226.2 → XP_030108086.1  histone-lysine N-methyltransferase EHMT1 isoform X32

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:696 → 922
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:747 → 778
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:752 → 845
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:978 → 1208
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  6. XM_030252224.2 → XP_030108084.1  histone-lysine N-methyltransferase EHMT1 isoform X29

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:703 → 929
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:754 → 785
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:759 → 852
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:985 → 1215
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  7. XM_030252229.2 → XP_030108089.1  histone-lysine N-methyltransferase EHMT1 isoform X36

    UniProtKB/TrEMBL
    E9Q5A3
    Conserved Domains (4) summary
    PHA03095
    Location:672 → 898
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:723 → 754
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:728 → 821
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:954 → 1184
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  8. XM_006498426.2 → XP_006498489.1  histone-lysine N-methyltransferase EHMT1 isoform X6

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:760 → 986
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:811 → 842
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:816 → 909
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1042 → 1272
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  9. XM_036162715.1 → XP_036018608.1  histone-lysine N-methyltransferase EHMT1 isoform X30

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (5) summary
    PHA03095
    Location:698 → 924
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:749 → 780
    ANK; ANK repeat [structural motif]
    cd10535
    Location:980 → 1210
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
    pfam12796
    Location:754 → 847
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:460 → 590
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

  10. XM_006498432.2 → XP_006498495.1  histone-lysine N-methyltransferase EHMT1 isoform X20

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:715 → 941
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:766 → 797
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:771 → 864
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:997 → 1227
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  11. XM_030252217.1 → XP_030108077.1  histone-lysine N-methyltransferase EHMT1 isoform X21

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:713 → 939
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:764 → 795
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:769 → 862
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:995 → 1225
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  12. XM_017319336.1 → XP_017174825.1  histone-lysine N-methyltransferase EHMT1 isoform X28

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:705 → 931
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:756 → 787
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:761 → 854
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:987 → 1217
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  13. XM_030252228.1 → XP_030108088.1  histone-lysine N-methyltransferase EHMT1 isoform X35

    UniProtKB/TrEMBL
    E9Q5A3
    Conserved Domains (4) summary
    PHA03095
    Location:674 → 900
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:725 → 756
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:730 → 823
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:956 → 1186
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  14. XM_006498430.2 → XP_006498493.1  histone-lysine N-methyltransferase EHMT1 isoform X16

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:722 → 948
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:773 → 804
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:778 → 871
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1004 → 1234
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  15. XM_006498431.2 → XP_006498494.1  histone-lysine N-methyltransferase EHMT1 isoform X17

    UniProtKB/TrEMBL
    E9Q5A3
    Conserved Domains (4) summary
    PHA03095
    Location:720 → 946
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:771 → 802
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:776 → 869
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1002 → 1232
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  16. XM_006498422.2 → XP_006498485.1  histone-lysine N-methyltransferase EHMT1 isoform X1

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:768 → 994
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:819 → 850
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:824 → 917
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1050 → 1280
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  17. XM_030252216.2 → XP_030108076.1  histone-lysine N-methyltransferase EHMT1 isoform X22

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:713 → 939
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:764 → 795
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:769 → 862
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:995 → 1225
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  18. XM_030252208.2 → XP_030108068.1  histone-lysine N-methyltransferase EHMT1 isoform X7

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:759 → 985
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:810 → 841
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:815 → 908
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1041 → 1271
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  19. XM_030252225.2 → XP_030108085.1  histone-lysine N-methyltransferase EHMT1 isoform X31

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:697 → 923
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:748 → 779
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:753 → 846
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:979 → 1209
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  20. XM_030252219.2 → XP_030108079.1  histone-lysine N-methyltransferase EHMT1 isoform X24

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:712 → 938
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:763 → 794
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:768 → 861
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:994 → 1224
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  21. XM_030252207.2 → XP_030108067.1  histone-lysine N-methyltransferase EHMT1 isoform X5

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:760 → 986
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:811 → 842
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:816 → 909
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1042 → 1272
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  22. XM_006498423.3 → XP_006498486.1  histone-lysine N-methyltransferase EHMT1 isoform X2

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:767 → 993
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:818 → 849
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:823 → 916
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1049 → 1279
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  23. XM_030252221.2 → XP_030108081.1  histone-lysine N-methyltransferase EHMT1 isoform X25

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:711 → 937
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:762 → 793
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:767 → 860
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:993 → 1223
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  24. XM_036162716.1 → XP_036018609.1  histone-lysine N-methyltransferase EHMT1 isoform X33

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (5) summary
    PHA03095
    Location:695 → 921
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:746 → 777
    ANK; ANK repeat [structural motif]
    cd10535
    Location:977 → 1207
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
    pfam12796
    Location:751 → 844
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:457 → 587
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

  25. XM_030252222.1 → XP_030108082.1  histone-lysine N-methyltransferase EHMT1 isoform X26

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:710 → 936
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:761 → 792
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:766 → 859
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:992 → 1222
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  26. XM_030252209.1 → XP_030108069.1  histone-lysine N-methyltransferase EHMT1 isoform X8

    UniProtKB/TrEMBL
    Z4YJZ7
    Related
    ENSMUSP00000088906.6, ENSMUST00000091348.11
    Conserved Domains (4) summary
    PHA03095
    Location:758 → 984
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:809 → 840
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:814 → 907
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1040 → 1270
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  27. XM_030252230.1 → XP_030108090.1  histone-lysine N-methyltransferase EHMT1 isoform X37

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:671 → 897
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:722 → 753
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:727 → 820
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:953 → 1183
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  28. XM_030252214.1 → XP_030108074.1  histone-lysine N-methyltransferase EHMT1 isoform X18

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:719 → 945
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:770 → 801
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:775 → 868
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1001 → 1231
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  29. XM_030252215.1 → XP_030108075.1  histone-lysine N-methyltransferase EHMT1 isoform X19

    UniProtKB/TrEMBL
    H7CHP8
    Conserved Domains (4) summary
    PHA03095
    Location:717 → 943
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:768 → 799
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:773 → 866
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:999 → 1229
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  30. XM_006498424.2 → XP_006498487.1  histone-lysine N-methyltransferase EHMT1 isoform X3

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:765 → 991
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:816 → 847
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:821 → 914
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1047 → 1277
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  31. XM_006498425.3 → XP_006498488.1  histone-lysine N-methyltransferase EHMT1 isoform X4

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:761 → 987
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:812 → 843
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:817 → 910
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1043 → 1273
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  32. XM_030252213.2 → XP_030108073.1  histone-lysine N-methyltransferase EHMT1 isoform X15

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:724 → 950
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:775 → 806
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:780 → 873
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1006 → 1236
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  33. XM_030252231.2 → XP_030108091.1  histone-lysine N-methyltransferase EHMT1 isoform X38

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:661 → 887
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:712 → 743
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:717 → 810
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:943 → 1173
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  34. XM_036162713.1 → XP_036018606.1  histone-lysine N-methyltransferase EHMT1 isoform X13

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (5) summary
    PHA03095
    Location:731 → 957
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:782 → 813
    ANK; ANK repeat [structural motif]
    cd10535
    Location:1013 → 1243
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
    pfam12796
    Location:787 → 880
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:493 → 623
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

  35. XM_036162712.1 → XP_036018605.1  histone-lysine N-methyltransferase EHMT1 isoform X12

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (5) summary
    PHA03095
    Location:733 → 959
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:784 → 815
    ANK; ANK repeat [structural motif]
    cd10535
    Location:1015 → 1245
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
    pfam12796
    Location:789 → 882
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:495 → 625
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

  36. XM_030252211.2 → XP_030108071.1  histone-lysine N-methyltransferase EHMT1 isoform X14

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:726 → 952
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:777 → 808
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:782 → 875
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1008 → 1238
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  37. XM_030252212.2 → XP_030108072.1  histone-lysine N-methyltransferase EHMT1 isoform X15

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:724 → 950
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:775 → 806
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:780 → 873
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1006 → 1236
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  38. XM_017319335.2 → XP_017174824.1  histone-lysine N-methyltransferase EHMT1 isoform X11

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (4) summary
    PHA03095
    Location:742 → 968
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:793 → 824
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:798 → 891
    Ank_2; Ankyrin repeats (3 copies)
    cd10535
    Location:1024 → 1254
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

  39. XM_036162711.1 → XP_036018604.1  histone-lysine N-methyltransferase EHMT1 isoform X10

    UniProtKB/TrEMBL
    Z4YJZ7
    Conserved Domains (5) summary
    PHA03095
    Location:747 → 973
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:798 → 829
    ANK; ANK repeat [structural motif]
    cd10535
    Location:1029 → 1259
    SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
    pfam12796
    Location:803 → 896
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:509 → 639
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

RNA

  1. XR_003953746.2 RNA Sequence

  2. XR_374136.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DW34.2 GenPept UniProtKB/Swiss-Prot:Q5DW34

Gene LinkOut

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