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Ptgr2 prostaglandin reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 77219, updated on 25-Apr-2024

Summary

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Official Symbol
Ptgr2provided by MGI
Official Full Name
prostaglandin reductase 2provided by MGI
Primary source
MGI:MGI:1916372
See related
Ensembl:ENSMUSG00000072946 AllianceGenome:MGI:1916372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR-2; PRG-2; Zadh1; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; B830026H24Rik
Summary
Predicted to enable 15-oxoprostaglandin 13-oxidase activity. Predicted to be involved in prostaglandin metabolic process. Located in mitochondrion. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 20.2), kidney adult (RPKM 11.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 39.14 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84332011..84362606)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84285237..84315832)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene predicted gene, 46319 Neighboring gene STARR-seq mESC enhancer starr_32734 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution. Levin I, et al. Proteins, 2004 Aug 15. PMID 15229897
  2. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. Chou WL, et al. J Biol Chem, 2007 Jun 22. PMID 17449869
  3. TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. Yaguchi H, et al. J Biol Chem, 2012 Apr 6. PMID 22337885, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2
    Title: Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation.
  2. This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics
    Title: Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 13-prostaglandin reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables 13-prostaglandin reductase activity TAS
Traceable Author Statement
more info
  
enables 15-oxoprostaglandin 13-oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 15-oxoprostaglandin 13-oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
prostaglandin reductase 2
Names
15-oxoprostaglandin 13-reductase
zinc binding alcohol dehydrogenase, domain containing 1
zinc-binding alcohol dehydrogenase domain-containing protein 1
NP_001239554.1
NP_001239555.1
NP_084156.2
XP_006516432.1
XP_036013551.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252625.1 → NP_001239554.1  prostaglandin reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_001239554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK145232, AK159932, CD742484, CJ050177
    Consensus CDS
    CCDS36490.1
    UniProtKB/Swiss-Prot
    Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
    UniProtKB/TrEMBL
    Q3TXN1
    Related
    ENSMUSP00000119981.2, ENSMUST00000146377.8
    Conserved Domains (2) summary
    cd08293
    Location:1 → 345
    PTGR2; Prostaglandin reductase
    COG2130
    Location:4 → 347
    CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

  2. NM_001252626.1 → NP_001239555.1  prostaglandin reductase 2 isoform 2

    See identical proteins and their annotated locations for NP_001239555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' region, which includes an alternate AUG start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK007522, AK168895, CD742484, CJ050177
    UniProtKB/TrEMBL
    Q3TXN1
    Conserved Domains (1) summary
    cd08293
    Location:2 → 296
    PTGR2; Prostaglandin reductase

  3. NM_029880.3 → NP_084156.2  prostaglandin reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_084156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK159932, CD742484, CJ050177
    Consensus CDS
    CCDS36490.1
    UniProtKB/Swiss-Prot
    Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
    UniProtKB/TrEMBL
    Q3TXN1
    Related
    ENSMUSP00000115704.2, ENSMUST00000123614.8
    Conserved Domains (2) summary
    cd08293
    Location:1 → 345
    PTGR2; Prostaglandin reductase
    COG2130
    Location:4 → 347
    CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84332011..84362606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516369.1 → XP_006516432.1  prostaglandin reductase 2 isoform X1

    UniProtKB/TrEMBL
    Q3TXN1
    Conserved Domains (1) summary
    cl16912
    Location:1 → 288
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. XM_036157658.1 → XP_036013551.1  prostaglandin reductase 2 isoform X2

    Conserved Domains (1) summary
    cl16912
    Location:2 → 239
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDQ1.2 GenPept UniProtKB/Swiss-Prot:Q8VDQ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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