Ifna1 interferon, alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ifna1provided by RGD
Full Name: interferon, alpha 1provided by RGD
Primary source: RGD:1306135
See related: Ensembl:ENSRNOG00000068703 AllianceGenome:RGD:1306135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ifna5; If1ai3
Summary: Involved in defense response to virus. Predicted to be integral component of membrane. Biomarker of osteoarthritis. Orthologous to human IFNA13 (interferon alpha 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (108143240..108143809)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (103097356..103097925)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (106951822..106952908)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate that downregulation of LOC101928134 suppresses the synovial hyperplasia and cartilage destruction of Osteoarthritis (OA) rats via activation of JAK/STAT signaling pathway by upregulating IFNA1, providing a new candidate for the treatment of OA.
Title: Downregulation of long noncoding RNA LOC101928134 inhibits the synovial hyperplasia and cartilage destruction of osteoarthritis rats through the activation of the Janus kinase/signal transducers and activators of transcription signaling pathway by upregulating IFNA1.

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General gene information

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Markers

Ifna7 (e-PCR), detects polymorphism
- UniSTS:516867

Ifna1 (e-PCR), detects polymorphism
- UniSTS:143457

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon alpha family, gene 5

Names: interferon 1ai3; interferon alpha 6-like; interferon alpha-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.