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Gpr84 G protein-coupled receptor 84 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688730, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr84provided by RGD
Official Full Name
G protein-coupled receptor 84provided by RGD
Primary source
RGD:1585277
See related
Ensembl:ENSRNOG00000036834 AllianceGenome:RGD:1585277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human GPR84 (G protein-coupled receptor 84). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 13.2), Spleen (RPKM 3.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136322374..136324648, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134443904..134446173, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144934606..144937194, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear factor, erythroid 2 Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene zinc finger protein 385A Neighboring gene uncharacterized LOC134479585 Neighboring gene integrin subunit alpha 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. Suzuki M, et al. J Biol Chem, 2013 Apr 12. PMID 23449982, Free PMC Article
  2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.
    Title: Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109509.1 → NP_001102979.1  G-protein coupled receptor 84

    See identical proteins and their annotated locations for NP_001102979.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474035
    UniProtKB/TrEMBL
    A6KD06, D4ACK0
    Related
    ENSRNOP00000052154.2, ENSRNOT00000055279.3
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    136322374..136324648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242449.5 → XP_006242511.1  G-protein coupled receptor 84 isoform X1

    See identical proteins and their annotated locations for XP_006242511.1

    UniProtKB/TrEMBL
    A6KD06, D4ACK0
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006242448.4 → XP_006242510.1  G-protein coupled receptor 84 isoform X1

    See identical proteins and their annotated locations for XP_006242510.1

    UniProtKB/TrEMBL
    A6KD06, D4ACK0
    Conserved Domains (1) summary
    cd15210
    Location:21 → 381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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