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Zfp740 zinc finger protein 740 [ Mus musculus (house mouse) ]

Gene ID: 68744, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp740provided by MGI
Official Full Name
zinc finger protein 740provided by MGI
Primary source
MGI:MGI:1915994
See related
Ensembl:ENSMUSG00000046897 AllianceGenome:MGI:1915994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf740; 1110034O07Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human ZNF740 (zinc finger protein 740). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.0), CNS E14 (RPKM 22.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F2; 15 57.37 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102112080..102124045)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102203506..102215610)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E5519 Neighboring gene STARR-seq mESC enhancer starr_39822 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055434-102055734 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055789-102056089 Neighboring gene integrin beta 7 Neighboring gene STARR-seq mESC enhancer starr_39826 Neighboring gene STARR-seq mESC enhancer starr_39827 Neighboring gene retinoic acid receptor, gamma Neighboring gene STARR-seq mESC enhancer starr_39828

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 740

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289690.2 → NP_001276619.1  zinc finger protein 740 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123791
    Conserved Domains (2) summary
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:127 → 152
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289691.1 → NP_001276620.1  zinc finger protein 740 isoform 2

    See identical proteins and their annotated locations for NP_001276620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123791
    Consensus CDS
    CCDS79416.1
    UniProtKB/TrEMBL
    A0A2R8W747
    Related
    ENSMUSP00000112985.2, ENSMUST00000118729.8
    Conserved Domains (2) summary
    sd00017
    Location:78 → 98
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:90 → 115
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289694.1 → NP_001276623.1  zinc finger protein 740 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both UTR's and has multiple coding region differences one of which results in a frameshift compared to variant 1. These differences also cause translation initiation at a downstream start codon compared to variant 1. This results in an isoform (3) that is shorter at the N-terminus and has a distinct C-termini, compared to isoform 1.
    Source sequence(s)
    AC123791
    Consensus CDS
    CCDS79415.1
    UniProtKB/TrEMBL
    D3Z4S9
    Related
    ENSMUSP00000113691.2, ENSMUST00000119168.8

  4. NM_001289695.1 → NP_001276624.1  zinc finger protein 740 isoform 4

    See identical proteins and their annotated locations for NP_001276624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123791, BC066011
    Consensus CDS
    CCDS70672.1
    UniProtKB/Swiss-Prot
    Q3UMS3, Q6NZQ6, Q8JZR3
    Related
    ENSMUSP00000113770.2, ENSMUST00000119800.8
    Conserved Domains (2) summary
    sd00017
    Location:90 → 110
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:102 → 127
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001358674.1 → NP_001345603.1  zinc finger protein 740 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC123791
    Conserved Domains (2) summary
    sd00017
    Location:103 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:115 → 140
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102112080..102124045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248732.2 → XP_030104592.1  zinc finger protein 740 isoform X1

    Related
    ENSMUSP00000122698.3, ENSMUST00000141465.9
    Conserved Domains (2) summary
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:127 → 152
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011245721.1 → XP_011244023.1  zinc finger protein 740 isoform X3

  3. XM_036159565.1 → XP_036015458.1  zinc finger protein 740 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:103 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:115 → 140
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006521336.2 → XP_006521399.1  zinc finger protein 740 isoform X4

    See identical proteins and their annotated locations for XP_006521399.1

    UniProtKB/TrEMBL
    A0A2R8W747
    Related
    ENSMUSP00000155827.2, ENSMUST00000230867.2
    Conserved Domains (2) summary
    sd00017
    Location:78 → 98
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:90 → 115
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153194.1: Suppressed sequence

    Description
    NM_153194.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZQ6.1 GenPept UniProtKB/Swiss-Prot:Q6NZQ6

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