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Myef2 myelin expression factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 679712, updated on 13-Apr-2024

Summary

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Official Symbol
Myef2provided by RGD
Official Full Name
myelin expression factor 2provided by RGD
Primary source
RGD:1306547
See related
Ensembl:ENSRNOG00000005258 AllianceGenome:RGD:1306547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mRNA binding activity. Predicted to be involved in myotube differentiation; neuron differentiation; and regulation of RNA metabolic process. Predicted to be part of post-mRNA release spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 256.7), Thymus (RPKM 233.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (132791694..132827572, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112338241..112374122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117353490..117389582, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555070 Neighboring gene uncharacterized LOC134486433 Neighboring gene uncharacterized LOC108350455 Neighboring gene solute carrier family 24 member 5 Neighboring gene cortexin 2 Neighboring gene solute carrier family 12 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. McDermott JC, et al. Mol Cell Biol, 1993 Apr. PMID 8455629, Free PMC Article
  2. Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene. Haas S, et al. J Biol Chem, 1995 May 26. PMID 7539003
  3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109392

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myelin expression factor 2
Names
myelin basic protein expression factor 2, repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013205.3 → NP_001013223.2  myelin expression factor 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K402, D4AEI5
    Related
    ENSRNOP00000072845.2, ENSRNOT00000081533.2
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515 → 591
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    132791694..132827572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234931.4 → XP_006234993.1  myelin expression factor 2 isoform X5

    UniProtKB/TrEMBL
    D4AEI5
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 563
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:491 → 567
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  2. XM_006234932.4 → XP_006234994.1  myelin expression factor 2 isoform X6

    UniProtKB/TrEMBL
    D4AEI5
    Related
    ENSRNOP00000077919.1
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 546
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:474 → 550
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  3. XM_006234930.3 → XP_006234992.1  myelin expression factor 2 isoform X4

    UniProtKB/TrEMBL
    D4AEI5
    Related
    ENSRNOP00000081666.1
    Conserved Domains (4) summary
    TIGR01628
    Location:115 → 570
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12658
    Location:92 → 167
    RRM1_MYEF2; RNA recognition motif 1 (RRM1) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12660
    Location:224 → 299
    RRM2_MYEF2; RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:498 → 574
    RRM3_MYEF2; RNA recognition motif 3 (RRM3) found in vertebrate myelin expression factor 2 (MEF-2)

  4. XM_063284535.1 → XP_063140605.1  myelin expression factor 2 isoform X1

  5. XM_063284536.1 → XP_063140606.1  myelin expression factor 2 isoform X2

  6. XM_063284537.1 → XP_063140607.1  myelin expression factor 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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