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Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 [ Mus musculus (house mouse) ]

Gene ID: 67464, updated on 8-Feb-2024

Summary

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Official Symbol
Entpd4provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 4provided by MGI
Primary source
MGI:MGI:1914714
See related
Ensembl:ENSMUSG00000095463 AllianceGenome:MGI:1914714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lysal1; mKIAA0392; 1200014F22Rik; 4930513O14Rik; A430102M06Rik
Summary
Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in UDP catabolic process. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 84.7), kidney adult (RPKM 55.5) and 26 other tissues See more
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Genomic context

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Location:
14 D2; 14 36.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69574600..69604191)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69337151..69366742)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41197 Neighboring gene syncytin b Neighboring gene predicted gene, 16677 Neighboring gene predicted gene, 53864 Neighboring gene predicted gene, 16867 Neighboring gene predicted gene, 21451 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69896143-69896444 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69903084-69903385 Neighboring gene STARR-seq mESC enhancer starr_37056 Neighboring gene predicted gene 27179 Neighboring gene predicted gene, 41194

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. First apyrase splice variants have different enzymatic properties. Biederbick A, et al. J Biol Chem, 2000 Jun 23. PMID 10858452
  2. Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. Boschen KE, et al. Dis Model Mech, 2021 Jun 1. PMID 34137816, Free PMC Article
  3. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, et al. Exp Neurol, 2016 Sep. PMID 27163549, Free PMC Article
  4. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Cui CY, et al. Hum Mol Genet, 2007 Nov 1. PMID 17673451
  5. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CTP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing small molecule catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 4
Names
NTPDase 4
UDPase
lysosomal apyrase-like 1
lysosomal apyrase-like protein of 70 kDa
uridine-diphosphatase
NP_001347281.1
NP_080450.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360352.1 → NP_001347281.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1. This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4B.
    Source sequence(s)
    AK004761, AK031065, BY276189, CX224148
    UniProtKB/TrEMBL
    Q8CHF7
    Conserved Domains (1) summary
    cl17037
    Location:82 → 532
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_026174.3 → NP_080450.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 1

    See identical proteins and their annotated locations for NP_080450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4B.
    Source sequence(s)
    AK004761, AK031065, BY276189
    Consensus CDS
    CCDS27240.1
    UniProtKB/Swiss-Prot
    Q9DBT4
    UniProtKB/TrEMBL
    Q8CHF7
    Related
    ENSMUSP00000138944.2, ENSMUST00000184973.8
    Conserved Domains (1) summary
    cl17037
    Location:82 → 540
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    69574600..69604191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBT4.1 GenPept UniProtKB/Swiss-Prot:Q9DBT4

Gene LinkOut

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