Slc6a19 solute carrier family 6 member 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a19provided by RGD
Official Full Name: solute carrier family 6 member 19provided by RGD
Primary source: RGD:1594328
See related: Ensembl:ENSRNOG00000026501 AllianceGenome:RGD:1594328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B0at1
Summary: Predicted to enable neutral amino acid transmembrane transporter activity. Involved in response to nutrient. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be integral component of plasma membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Hartnup disease and iminoglycinuria. Orthologous to human SLC6A19 (solute carrier family 6 member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 528.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31414744..31434932)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29586191..29604964)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32199869..32218628)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of the chronic dietary regulation of B0AT1, ACE2 and CD13 by different diets revealed an increased B0AT1 protein expression under amino acid-supplemented diet in the proximal section but not in the distal one and for ACE2 protein expression a reverse localization of the effect.
Title: Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine.
Leptin controls active glutamine entry through reduction of both B(0)AT1 and ASCT2 protein trafficking to the apical plasma membrane and modulation of their gene expression.
Title: Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1.
Roux-en-Y gastric bypass selectively increased glutamine absorption in biliopancreatic and Roux limbs by a mechanism involving increased B(0)AT1 expression.
Title: Roux-en-Y gastric bypass alters small intestine glutamine transport in the obese Zucker rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium-dependent neutral amino acid transporter B(0)AT1

Names: b(0)AT1; neutral amino acid transporter; solute carrier family 6 (neurotransmitter transporter), member 19; solute carrier family 6 (neutral amino acid transporter), member 19; system B(0) neutral amino acid transporter AT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039722.3 → NP_001034811.2 sodium-dependent neutral amino acid transporter B(0)AT1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

A4ZVM8, Q2A865

UniProtKB/TrEMBL

A6JUW5, A6JUW8

Related

ENSRNOP00000028917.2, ENSRNOT00000036714.4

Conserved Domains (1) summary

cl00456
Location:32 → 612

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31414744..31434932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090198.2 → XP_038946126.1 sodium-dependent neutral amino acid transporter B(0)AT1 isoform X1

UniProtKB/TrEMBL

A6JUW6, A6JUW8

Conserved Domains (1) summary

cl00456
Location:21 → 517

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain