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rpa2 replication protein A2 [ Danio rerio (zebrafish) ]

Gene ID: 65226, updated on 11-Apr-2024

Summary

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Official Symbol
rpa2provided by ZNC
Official Full Name
replication protein A2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010131-3
See related
Ensembl:ENSDARG00000037188 AllianceGenome:ZFIN:ZDB-GENE-010131-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rpa; zgc:109822; ik:tdsubc_2g1; xx:tdsubc_2g1
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in DNA replication; double-strand break repair via homologous recombination; and nucleotide-excision repair. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region; nucleus; and site of double-strand break. Orthologous to several human genes including RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4746593..4769967, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4917304..4940678, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene sphingomyelin phosphodiesterase acid like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene ubiquitin protein ligase E3D Neighboring gene trophoblast glycoprotein b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of replication protein A p32 complementary DNA in zebrafish (Danio rerio). Lee JS, et al. Mar Biotechnol (NY), 2002 Jan. PMID 14961282
  2. Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Takahashi N, et al. Nucleic Acids Res, 2005 Aug 1. PMID 16061934, Free PMC Article
  3. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  4. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. Xia H, et al. Genetics, 2018 Feb. PMID 29196300, Free PMC Article
  5. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication protein A 32 kDa subunit
Names
RPA p32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131711.2 → NP_571786.2  replication protein A 32 kDa subunit

    See identical proteins and their annotated locations for NP_571786.2

    Status: VALIDATED

    Source sequence(s)
    BC095005
    UniProtKB/TrEMBL
    B5DDC8, F6NPP7, Q504I6
    Related
    ENSDARP00000054077.6, ENSDART00000054078.8
    Conserved Domains (3) summary
    COG5235
    Location:20 → 267
    RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
    cd04478
    Location:69 → 163
    RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
    pfam08784
    Location:162 → 262
    RPA_C; Replication protein A C terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    4746593..4769967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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