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Aldh3a2 aldehyde dehydrogenase 3 family, member A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65183, updated on 11-Apr-2024

Summary

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Official Symbol
Aldh3a2provided by RGD
Official Full Name
aldehyde dehydrogenase 3 family, member A2provided by RGD
Primary source
RGD:61866
See related
Ensembl:ENSRNOG00000002342 AllianceGenome:RGD:61866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aldh4; FALDH
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and response to reactive oxygen species. Located in cytosol; endoplasmic reticulum; and nucleus. Is extrinsic component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1466.6), Lung (RPKM 194.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46427789..46448449, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45928313..45949366, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47525486..47546535, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095325 Neighboring gene RAS related 2, pseudogene 1 Neighboring gene uncharacterized LOC120095114 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene solute carrier family 47 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase. Miyauchi K, et al. J Biol Chem, 1991 Oct 15. PMID 1717467
  2. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Keller MA, et al. Nat Commun, 2014 Jul 22. PMID 25047030, Free PMC Article
  3. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Lloyd MD, et al. J Enzyme Inhib Med Chem, 2007 Oct. PMID 18035827
  4. Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid. van den Brink DM, et al. Mol Genet Metab, 2004 May. PMID 15110319
  5. Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin. Demozay D, et al. J Biol Chem, 2004 Feb 20. PMID 14638678

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FALDH has roles in insulin action and is deregulated in states associated with altered insulin signaling
    Title: Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-alcohol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-alcohol oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain-aldehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain-aldehyde dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables medium-chain-aldehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain-aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain-aldehyde dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in formaldehyde metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hexadecanal metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexadecanal metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hexadecanal metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in phytol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phytol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sesquiterpenoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 3 member A2
Names
alcohol dehydrogenase family 3, subfamily A2
aldehyde dehydrogenase 3A2
aldehyde dehydrogenase 4
aldehyde dehydrogenase family 3, subfamily A2
fatty aldehyde dehydrogenase
microsomal aldehyde dehydrogenase
msALDH
NP_113919.2
XP_006246591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031731.2 → NP_113919.2  aldehyde dehydrogenase family 3 member A2

    See identical proteins and their annotated locations for NP_113919.2

    Status: VALIDATED

    Source sequence(s)
    CB727458, CV109765, DW311997, EV780143, M73714
    UniProtKB/Swiss-Prot
    P30839
    UniProtKB/TrEMBL
    A6HF75
    Related
    ENSRNOP00000061762.2, ENSRNOT00000066109.4
    Conserved Domains (1) summary
    cd07132
    Location:5 → 444
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    46427789..46448449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246529.3 → XP_006246591.1  aldehyde dehydrogenase family 3 member A2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF13, G3V9W6
    Related
    ENSRNOP00000091330.1
    Conserved Domains (1) summary
    cd07132
    Location:82 → 521
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30839.1 GenPept UniProtKB/Swiss-Prot:P30839

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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