Kcnk12 potassium two pore domain channel subfamily K member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk12provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 12provided by RGD
Primary source: RGD:68940
See related: Ensembl:ENSRNOG00000016110 AllianceGenome:RGD:68940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: THIK-2
Summary: Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905828.1 and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (12492609..12544250)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (6740147..6790664)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (11373917..11494459, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the characteristics of THIK-2 channels can be analysed in heterologous expression systems by using trafficking and/or gating mutants
Title: Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.
THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 12

Names: potassium channel, subfamily K, member 12; potassium channel, two pore domain subfamily K, member 12; tandem pore domain halothane-inhibited potassium channel 2; tandem pore domain potassium channel THIK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022292.2 → NP_071628.1 potassium channel subfamily K member 12

See identical proteins and their annotated locations for NP_071628.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q9ERS1

UniProtKB/TrEMBL

A6H9C8

Related

ENSRNOP00000021570.1, ENSRNOT00000021570.3

Conserved Domains (1) summary

pfam07885
Location:222 → 304

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

12492609..12544250

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112871.2 → XP_038968799.1 potassium channel subfamily K member 12 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZT0

Related

ENSRNOP00000084526.1

Conserved Domains (1) summary

pfam07885
Location:313 → 395

Ion_trans_2; Ion channel
XM_039112873.2 → XP_038968801.1 potassium channel subfamily K member 12 isoform X2

Conserved Domains (1) summary

pfam07885
Location:89 → 171

Ion_trans_2; Ion channel