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Eral1 Era like 12S mitochondrial rRNA chaperone 1 [ Mus musculus (house mouse) ]

Gene ID: 57837, updated on 5-Mar-2024

Summary

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Official Symbol
Eral1provided by MGI
Official Full Name
Era like 12S mitochondrial rRNA chaperone 1provided by MGI
Primary source
MGI:MGI:1889295
See related
Ensembl:ENSMUSG00000020832 AllianceGenome:MGI:1889295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Era; M-ERA; MERA-S; MERA-W; 2610524P08Rik; 9130407C09Rik
Summary
Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in ribosomal small subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol and mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in ureter and urinary system. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.4), mammary gland adult (RPKM 17.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77964202..77971209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78073376..78080383, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57805 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144 Neighboring gene family with sequence similarity 222, member B Neighboring gene STARR-seq mESC enhancer starr_30086 Neighboring gene U6 small nuclear RNA associated LSM6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10694 Neighboring gene STARR-seq mESC enhancer starr_30088 Neighboring gene TNF receptor associated factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Li S, et al. Cell Rep, 2021 Jan 19. PMID 33472079
  2. Global Proteome of LonP1(+/-) Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes. Key J, et al. Int J Mol Sci, 2019 Sep 12. PMID 31547314, Free PMC Article
  3. CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. Szczepanowska K, et al. EMBO J, 2016 Dec 1. PMID 27797820, Free PMC Article
  4. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. Britton RA, et al. Genomics, 2000 Jul 1. PMID 10945472
  5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of membrane estrogen receptor alpha (ERalpha) in the rapid regulation of male sexual behavior.
    Title: Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior.
  2. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
    Title: The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
  3. LonP1(+/-) mouse embryonal fibroblasts also showed Eral1 accumulation, but no systematic effect on mitoribosomal subunits.
    Title: Global Proteome of LonP1(+/-) Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.
  4. The authors show that the defect in mitoribosomal assembly is a consequence of the accumulation of ERAL1, a putative 12S rRNA chaperone, and novel ClpXP substrate.
    Title: CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTPase Era, mitochondrial
Names
CEGA
ERA-W
ERA-like GTPase
ERA-like protein 1
GTP-binding protein era homolog
conserved ERA-like GTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022313.2 → NP_071708.2  GTPase Era, mitochondrial

    See identical proteins and their annotated locations for NP_071708.2

    Status: VALIDATED

    Source sequence(s)
    AF190730, AK012155, BY158323
    Consensus CDS
    CCDS48856.1
    UniProtKB/Swiss-Prot
    Q6NV78, Q8VE60, Q925U1, Q9CZU4
    Related
    ENSMUSP00000021183.4, ENSMUST00000021183.4
    Conserved Domains (3) summary
    cd04163
    Location:111 → 327
    Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
    COG1159
    Location:108 → 437
    Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
    pfam07650
    Location:363 → 431
    KH_2; KH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77964202..77971209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZU4.1 GenPept UniProtKB/Swiss-Prot:Q9CZU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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