wnt2bb wingless-type MMTV integration site family, member 2Bb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt2bbprovided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 2Bbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060824-6
See related: Ensembl:ENSDARG00000032234 AllianceGenome:ZFIN:ZDB-GENE-060824-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cytokine activity and frizzled binding activity. Involved in liver development. Acts upstream of or within several processes, including angiogenesis; hepaticobiliary system development; and swim bladder development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; heart; mesoderm; nervous system; and primordial vasculature. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (27743550..27768785)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (27724411..27749646)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that this synergistic reduction of Wnt signaling contributes to the loss of hepatopancreas specification in wnt2bbs404; hnf1bas430 double mutants.
Title: Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb.
show that sequential functions of Wnt2bb and Wnt2 control liver specification and proliferation in zebrafish
Title: Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	TAS Traceable Author Statement more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within common bile duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gallbladder development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatic duct development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hepaticobiliary system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IMP Inferred from Mutant Phenotype more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swim bladder development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: wingless-type MMTV integration site family, member 2Bb

Names: prometheus; prt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.