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KLHL24 kelch like family member 24 [ Homo sapiens (human) ]

Gene ID: 54800, updated on 23-Mar-2024

Summary

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Official Symbol
KLHL24provided by HGNC
Official Full Name
kelch like family member 24provided by HGNC
Primary source
HGNC:HGNC:25947
See related
Ensembl:ENSG00000114796 MIM:611295; AllianceGenome:HGNC:25947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRE1; EBS6; CMH29; EBSSH; KRIP6
Summary
The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in heart (RPKM 9.5), thyroid (RPKM 9.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q27.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (183635623..183684519)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (186445098..186493998)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183353411..183402307)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PRICKLE1 pseudogene 1 Neighboring gene uncharacterized LOC105374248 Neighboring gene uncharacterized LOC107986162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14946 Neighboring gene NANOG hESC enhancer GRCh37_chr3:183384502-183385010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14947 Neighboring gene YEATS domain containing 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:183527422-183528621 Neighboring gene YEATS2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:183535409-183536020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14950 Neighboring gene MAP6 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A translation re-initiation variant in KLHL24 also causes epidermolysis bullosa simplex and dilated cardiomyopathy via intermediate filament degradation. Vermeer MCSC, et al. Br J Dermatol, 2022 Dec. PMID 35975634, Free PMC Article
  2. Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight in congenital skin defects and fragility of epidermolysis bullosa simplex with cardiomyopathy. Logli E, et al. Hum Mol Genet, 2022 Apr 22. PMID 34740256, Free PMC Article
  3. Phenotypic Features of Epidermolysis Bullosa Simplex due to KLHL24 Mutations in 3 Italian Cases. El Hachem M, et al. Acta Derm Venereol, 2019 Feb 1. PMID 30226531
  4. Cardiomyopathy in patients with epidermolysis bullosa simplex with mutations in KLHL24. Yenamandra VK, et al. Br J Dermatol, 2018 Nov. PMID 29779254
  5. The "Kelch" Surprise: KLHL24, a New Player in the Pathogenesis of Skin Fragility. Has C. J Invest Dermatol, 2017 Jun. PMID 28532758

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EBS in Children with De Novo Pathogenic Variants Disturbing Krt14.
    Title: EBS in Children with De Novo Pathogenic Variants Disturbing Krt14.
  2. A translation re-initiation variant in KLHL24 also causes epidermolysis bullosa simplex and dilated cardiomyopathy via intermediate filament degradation.
    Title: A translation re-initiation variant in KLHL24 also causes epidermolysis bullosa simplex and dilated cardiomyopathy via intermediate filament degradation.
  3. Keratin 14 Degradation and Aging in Epidermolysis Bullosa Simplex due to KLHL24 Gain-of-Function Variants.
    Title: Keratin 14 Degradation and Aging in Epidermolysis Bullosa Simplex due to KLHL24 Gain-of-Function Variants.
  4. Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight in congenital skin defects and fragility of epidermolysis bullosa simplex with cardiomyopathy.
    Title: Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight in congenital skin defects and fragility of epidermolysis bullosa simplex with cardiomyopathy.
  5. we show that mutations in KLHL24 cause HCM in humans. Using genome-wide linkage analysis and exome sequencing, we identified homozygous mutations in KLHL24 in two consanguineous families with HCM
    Title: Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24.
  6. Study in a Dutch family propose that a KLHL24 mutation cause a syndromic rather than a skin-only type of epidermolysis bullosa, in which cardiomyopathy may be a dominant symptom.
    Title: Cardiomyopathy in patients with epidermolysis bullosa simplex with mutations in KLHL24.
  7. Case Reports: Epidermolysis bullosa simplex -KLHL24 is characterized by congenital skin defects of the lower limbs, which heal rapidly, leaving hypopigmented-atrophic patches and peculiar stellate and linear raised scars.
    Title: Phenotypic Features of Epidermolysis Bullosa Simplex due to KLHL24 Mutations in 3 Italian Cases.
  8. KLHL24 mutation is associated in the pathogenesis of skin abnormalities and epidermolysis bullosa simplex.
    Title: The "Kelch" Surprise: KLHL24, a New Player in the Pathogenesis of Skin Fragility.
  9. KLHL24 Mutation is associated with epidermolysis bullosa.
    Title: Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility.
  10. findings identify KLHL24 mutations as a cause of skin fragility and identify a role for KLHL24 in maintaining the balance between intermediate filament stability and degradation required for skin integrity
    Title: Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in desmosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 24
Names
kainate receptor interacting protein for GluR6
kelch-like 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349413.1 → NP_001336342.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  2. NM_001349414.1 → NP_001336343.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, and 3-6, encode isoform a.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  3. NM_001349415.1 → NP_001336344.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  4. NM_001349416.1 → NP_001336345.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6 encodes isoform a.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  5. NM_001349417.1 → NP_001336346.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4, and 6, encodes isoform a.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  6. NM_001349418.1 → NP_001336347.1  kelch-like protein 24 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  7. NM_001349419.1 → NP_001336348.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  8. NM_001349420.1 → NP_001336349.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 7, 8, and 10-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  9. NM_001349421.1 → NP_001336350.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 7-9 and 11-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  10. NM_001349422.1 → NP_001336351.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 7-10 and 12-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  11. NM_001349423.1 → NP_001336352.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 7-11 and 13-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  12. NM_001349424.1 → NP_001336353.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 7-12 and 14-15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  13. NM_001349425.1 → NP_001336354.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 7-13 and 15, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  14. NM_001349426.1 → NP_001336355.1  kelch-like protein 24 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 7-14, encodes isoform b.
    Source sequence(s)
    AC068769
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Related
    ENSP00000419010.1, ENST00000476808.1
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  15. NM_001349428.1 → NP_001336357.1  kelch-like protein 24 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform c.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:264 → 310
    Kelch; Kelch domain
    sd00038
    Location:73 → 112
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:46 → 285
    BTB; Broad-Complex, Tramtrack and Bric a brac

  16. NM_001349429.1 → NP_001336358.1  kelch-like protein 24 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform c.
    Source sequence(s)
    AC068769
    Conserved Domains (3) summary
    smart00612
    Location:264 → 310
    Kelch; Kelch domain
    sd00038
    Location:73 → 112
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:46 → 285
    BTB; Broad-Complex, Tramtrack and Bric a brac

  17. NM_017644.3 → NP_060114.2  kelch-like protein 24 isoform b

    See identical proteins and their annotated locations for NP_060114.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 8-15, encodes isoform b.
    Source sequence(s)
    AC068769, AY422472
    Consensus CDS
    CCDS3246.1
    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Related
    ENSP00000242810.6, ENST00000242810.11
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RNA

  1. NR_146169.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068769

  2. NR_146170.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068769

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    183635623..183684519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448371.1 → XP_047304327.1  kelch-like protein 24 isoform X1

  2. XM_047448372.1 → XP_047304328.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  3. XM_005247552.3 → XP_005247609.1  kelch-like protein 24 isoform X2

    See identical proteins and their annotated locations for XP_005247609.1

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9
    Related
    ENSP00000395012.1, ENST00000454652.6
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  4. XM_017006655.2 → XP_016862144.1  kelch-like protein 24 isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  5. XM_017006653.2 → XP_016862142.1  kelch-like protein 24 isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  6. XM_047448373.1 → XP_047304329.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  7. XM_047448374.1 → XP_047304330.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  8. XM_017006658.2 → XP_016862147.1  kelch-like protein 24 isoform X1

    Conserved Domains (3) summary
    smart00612
    Location:570 → 616
    Kelch; Kelch domain
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:62 → 591
    BTB; Broad-Complex, Tramtrack and Bric a brac

  9. XM_047448375.1 → XP_047304331.1  kelch-like protein 24 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    186445098..186493998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346960.1 → XP_054202935.1  kelch-like protein 24 isoform X1

  2. XM_054346965.1 → XP_054202940.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  3. XM_054346964.1 → XP_054202939.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  4. XM_054346961.1 → XP_054202936.1  kelch-like protein 24 isoform X1

  5. XM_054346963.1 → XP_054202938.1  kelch-like protein 24 isoform X1

  6. XM_054346966.1 → XP_054202941.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  7. XM_054346967.1 → XP_054202942.1  kelch-like protein 24 isoform X2

    UniProtKB/Swiss-Prot
    A5PLN8, Q6TFL4, Q9H620, Q9NXT9

  8. XM_054346962.1 → XP_054202937.1  kelch-like protein 24 isoform X1

  9. XM_054346968.1 → XP_054202943.1  kelch-like protein 24 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TFL4.1 GenPept UniProtKB/Swiss-Prot:Q6TFL4

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