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MAPK8 mitogen-activated protein kinase 8 [ Bos taurus (cattle) ]

Gene ID: 539941, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK8provided by VGNC
Official Full Name
mitogen-activated protein kinase 8provided by VGNC
Primary source
VGNC:VGNC:31223
See related
BGD:BT10854; Ensembl:ENSBTAG00000007876
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
JNK1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (42712811..42813456)

Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344152 Neighboring gene protein tyrosine phosphatase non-receptor type 20 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC132344153 Neighboring gene WDFY family member 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling. Panzhinskiy E, et al. Cardiovasc Res, 2012 Aug 1. PMID 22735370, Free PMC Article
  2. Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK. Karahashi H, et al. J Immunol, 2009 Jun 1. PMID 19454725, Free PMC Article
  3. Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide. Chen SC, et al. Atherosclerosis, 2008 Dec. PMID 18377912
  4. Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways. Kishore R, et al. Circ Res, 2003 Nov 14. PMID 14576193
  5. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. Zhang W, et al. J Biol Chem, 2005 May 13. PMID 15755722

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
    Title: Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling.
  2. ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
    Title: Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide.
  3. JNK plays an important role in the induction of apoptosis in transformed bovine brain endothelial cells stimulated by LPS
    Title: Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK.
  4. PKD is a critical mediator in H2O2- but not TNF-induced ASK1-JNK signaling
    Title: Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.
  5. These data suggest a differential requirement of JNK1 and p38 MAPK in TNF regulation of E2F1. Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF-mediated EC dysfunction.
    Title: Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 8
NP_001179903.2
XP_005226640.1
XP_005226642.1
XP_005226643.1
XP_005226644.1
XP_010819018.1
XP_010819019.1
XP_010819020.1
XP_010819021.1
XP_024842508.1
XP_024842509.1
XP_024842510.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192974.2 → NP_001179903.2  mitogen-activated protein kinase 8

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000028
    UniProtKB/TrEMBL
    A0A3Q1MG18, F1MM73
    Related
    ENSBTAP00000010361.3, ENSBTAT00000010361.4
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42712811..42813456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986740.2 → XP_024842508.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MG18
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_010820717.4 → XP_010819019.1  mitogen-activated protein kinase 8 isoform X1

    See identical proteins and their annotated locations for XP_010819019.1

    UniProtKB/TrEMBL
    A0A3Q1MG18
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. XM_024986742.2 → XP_024842510.1  mitogen-activated protein kinase 8 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1MG18, F1MM73
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_010820718.4 → XP_010819020.1  mitogen-activated protein kinase 8 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LWJ8
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_005226587.5 → XP_005226644.1  mitogen-activated protein kinase 8 isoform X8

    UniProtKB/TrEMBL
    A0A3Q1LWJ8
    Related
    ENSBTAP00000079922.1, ENSBTAT00000118937.1
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_005226585.5 → XP_005226642.1  mitogen-activated protein kinase 8 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1NK45
    Related
    ENSBTAP00000072616.1, ENSBTAT00000084331.2
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_010820716.4 → XP_010819018.1  mitogen-activated protein kinase 8 isoform X1

    See identical proteins and their annotated locations for XP_010819018.1

    UniProtKB/TrEMBL
    A0A3Q1MG18
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_005226586.5 → XP_005226643.1  mitogen-activated protein kinase 8 isoform X7

    See identical proteins and their annotated locations for XP_005226643.1

    UniProtKB/TrEMBL
    A0A3Q1MG18, F1MM73
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. XM_005226583.5 → XP_005226640.1  mitogen-activated protein kinase 8 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1NK45
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  10. XM_024986741.2 → XP_024842509.1  mitogen-activated protein kinase 8 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1NK45
    Conserved Domains (1) summary
    cd07850
    Location:1 → 284
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  11. XM_010820719.4 → XP_010819021.1  mitogen-activated protein kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MG18
    Related
    ENSBTAP00000101408.1, ENSBTAT00000108406.1
    Conserved Domains (2) summary
    smart00220
    Location:26 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Nucleotide Protein Strain
Heading Accession and Version

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