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Tlr5 toll-like receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 53791, updated on 21-Apr-2024

Summary

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Official Symbol
Tlr5provided by MGI
Official Full Name
toll-like receptor 5provided by MGI
Primary source
MGI:MGI:1858171
See related
Ensembl:ENSMUSG00000079164 AllianceGenome:MGI:1858171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; and positive regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; olfactory epithelium; spinal cord; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 1.5), lung adult (RPKM 1.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H5; 1 86.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182782317..182804010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182954752..182976044)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 185 Neighboring gene sushi domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_03290 Neighboring gene STARR-seq mESC enhancer starr_03291 Neighboring gene STARR-seq mESC enhancer starr_03292 Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene predicted gene, 33747 Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Golonka RM, et al. Hepatol Commun, 2023 Jun 1. PMID 37219858, Free PMC Article
  2. TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy. Gonzalez C, et al. Commun Biol, 2023 Jan 12. PMID 36635337, Free PMC Article
  3. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. Mallaret G, et al. World J Gastroenterol, 2022 Aug 7. PMID 36157543, Free PMC Article
  4. Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice. Seong KJ, et al. Stem Cells, 2022 Mar 31. PMID 35304896
  5. Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock. Zhang Y, et al. J Immunol Res, 2021. PMID 34840990, Free PMC Article

See all (236) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.
    Title: TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.
  2. Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model.
    Title: Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model.
  3. Mucosal TLR5 activation controls healthspan and longevity.
    Title: Mucosal TLR5 activation controls healthspan and longevity.
  4. Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
    Title: Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
  5. Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
    Title: Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
  6. Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
    Title: Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
  7. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
    Title: Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
  8. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation.
    Title: Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation.
  9. Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.
    Title: Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.
  10. Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.
    Title: Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.
Submit: New GeneRIF Correction See all GeneRIFs (119)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor 5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
toll-like receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016928.4 → NP_058624.3  toll-like receptor 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC170917, FO082331
    Consensus CDS
    CCDS35815.1
    UniProtKB/TrEMBL
    Q05AH3, Q1ZZX0
    Related
    ENSMUSP00000141458.2, ENSMUST00000191820.3
    Conserved Domains (6) summary
    PRK15370
    Location:383 → 583
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:555 → 633
    PCC; polycystin cation channel protein
    sd00033
    Location:291 → 314
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:694 → 844
    TIR; TIR domain
    pfam13855
    Location:294 → 349
    LRR_8; Leucine rich repeat
    cd21340
    Location:92 → 181
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182782317..182804010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321698.2 → XP_017177187.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  2. XM_017321703.2 → XP_017177192.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Related
    ENSMUSP00000141318.3, ENSMUST00000193687.7
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  3. XM_017321699.3 → XP_017177188.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  4. XM_017321700.3 → XP_017177189.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  5. XM_017321697.3 → XP_017177186.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  6. XM_017321701.2 → XP_017177190.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  7. XM_017321704.2 → XP_017177193.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain

  8. XM_017321702.3 → XP_017177191.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YVY4, Q1ZZX0, Q8CB40
    Conserved Domains (5) summary
    PRK15370
    Location:397 → 597
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:569 → 647
    PCC; polycystin cation channel protein
    sd00033
    Location:305 → 328
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308 → 363
    LRR_8; Leucine rich repeat
    pfam01582
    Location:708 → 858
    TIR; TIR domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLF7.1 GenPept UniProtKB/Swiss-Prot:Q9JLF7

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