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MAP2K4 mitogen-activated protein kinase kinase 4 [ Bos taurus (cattle) ]

Gene ID: 526469, updated on 5-Mar-2024

Summary

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Official Symbol
MAP2K4provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase 4provided by VGNC
Primary source
VGNC:VGNC:31185
See related
BGD:BT29145; Ensembl:ENSBTAG00000012103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (30649006..30726941)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene shisa family member 6 Neighboring gene dynein axonemal heavy chain 9 Neighboring gene zinc finger protein 18 Neighboring gene uncharacterized LOC132343047 Neighboring gene microRNA mir-744 Neighboring gene small integral membrane protein 20-like Neighboring gene myocardin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC140244

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 4
NP_001092508.1
XP_005220426.1
XP_005220427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099038.1 → NP_001092508.1  dual specificity mitogen-activated protein kinase kinase 4

    See identical proteins and their annotated locations for NP_001092508.1

    Status: PROVISIONAL

    Source sequence(s)
    BC142195
    UniProtKB/TrEMBL
    A0A3Q1LTC6, A5PJP8
    Conserved Domains (2) summary
    smart00220
    Location:116 → 380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:108 → 398
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    30649006..30726941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005220369.5 → XP_005220426.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005220426.1

    UniProtKB/TrEMBL
    A0A3Q1LTC6, A0A3Q1N7I1
    Conserved Domains (2) summary
    smart00220
    Location:105 → 369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:97 → 387
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

  2. XM_005220370.3 → XP_005220427.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    See identical proteins and their annotated locations for XP_005220427.1

    UniProtKB/TrEMBL
    A0A3Q1LTC6
    Related
    ENSBTAP00000041598.3, ENSBTAT00000044085.4
    Conserved Domains (1) summary
    cd06616
    Location:34 → 324
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
Nucleotide Protein Strain
Heading Accession and Version

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